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- Bioss
- bs-11448P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11448P |
| 英文名称 | phospho-AANAT (Thr29) Antibody Blocking Peptide |
| 中文名称 | 磷酸化芳香胺N-乙酰化转移酶封闭多肽 |
| 英文别名 | p-AANAT(Thr29); p-AANAT(T29); AANAT(phospho Thr29); p-AANAT(phospho-T29); Serotonin N-acetyltransferase (phospho T29); AANAT (phospho-Thr29); AANAT; Arylalkylamine N acetyltransferase; SNAT_HUMAN; Serotonin N-acetyltransferase; SNAT; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Types of disease > Cancer Neuroscience > Neurology process > Circadian Rhythm > Hormones Neuroscience > Neurotransmitter > Biogenic Amines > Serotonin / 5HT |
| 亚基 | Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation (By similarity). |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. |
| 翻译后修饰 | cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. |
| 相似性 | Belongs to the acetyltransferase family. AANAT subfamily. Contains 1 N-acetyltransferase domain. |
| 功能 | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
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phospho-AANAT (Thr29) Antibody Blocking Peptide(bs-11448P)-500ug
￥1080
