Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-SAMHD1/MOP5 (bs-8060R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72 kD
Observed band size: 72 kD
- ￥1180 - 2800
- Bioss
- bs-8060R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 应用范围：
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8060R |
| 英文名称 | SAMHD1/MOP5 Rabbit pAb |
| 中文名称 | 单核细胞蛋白5抗体 |
| 英文别名 | DCIP; Dendritic cell derived IFNG induced protein; Dendritic cell-derived IFNG-induced protein; HD domain containing 1; HDDC1; Mg11; Monocyte protein 5; MOP 5; MOP5; OTTHUMP00000030889; SAM domain and HD domain 1; SAM domain and HD domain containing protein 1; SAM domain and HD domain-containing protein 1; SAMH1_HUMAN; Samhd1; SBBI88. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Cow, Horse, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SAMHD1/HDDC1/MOP5 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 72 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Interspecies Interaction > Host Immune Response Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in heart, skeletal muscle, spleen,liver, small intestine, placenta, lung and peripheral bloodleukocytes. No expression is seen in brain and thymus. |
| 翻译后修饰 | Phosphorylation at Thr-592 by CDK1 acts as a switch to control deoxynucleoside triphosphate (dNTPase)-dependent and -independent functions (PubMed:29670289). Phosphorylation at Thr-592 takes place in cycling cells: it reduces the stability of the homotetramer, impairing the dNTPase activity and subsequent ability to restrict infection by viruses (PubMed:23602554, PubMed:23601106, PubMed:26294762, PubMed:26431200). It also inhibits ability to suppress LINE-1 retrotransposon activity (PubMed:29610582). In contrast, phosphorylation at Thr-592 promotes DNA end resection at stalled replication forks in response to DNA damage (PubMed:29670289). |
| 相似性 | Belongs to the SAMHD1 family. Contains 1 HD domain. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Putative nuclease involved in innate immune response byacting as a negative regulator of the cell-intrinsic antiviralresponse. May play a role in mediating proinflammatory responses toTNF-alpha signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验相关实验
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
. Retrieved 2010-11-29. ^ Nielsen BS, Jørgensen S, Fog JU, Søkilde R, Christensen IJ, Hansen U, Brünner N, Baker A, Møller S, Nielsen HJ (October 2010). "High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival
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SAMHD1/MOP5 Rabbit pAb(bs-8060R)-50ul/100ul/200ul
￥1180 - 2800
