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- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-9696R |
| 英文名称 | C20orf19 Rabbit pAb |
| 中文名称 | 20号染色体开放阅读框19抗体 |
| 英文别名 | DKFZP586H021; HT013; KIZUNA; MGC102941; MGC141930; Uncharacterized protein C20orf19; KIZ_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Pig, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human KIZUNA/C20orf19 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 75 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚基 | Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2. |
| 亚细胞定位 | Cytoplasm, cytoskeleton, centrosome.Note=Localizes to centrosomes throughout the cell cycle. Aftercentrosome duplication, it usually remains associated only with themother centrosome, containing the older mature centriole andparticles surrounding it. During prophase, additional particlesaccumulate around both separating centrosomes. Does not accumulateat the microtubule minus ends, but instead localizes to thecentrosomes and centrosome-surrounding area in amicrotubule-independent and dependent manner, respectively. |
| 翻译后修饰 | Phosphorylation at Thr-379 by PLK1 is not needed forcentrosomal localization or pericentriolar material expansion butis indispensable for spindle-pole stabilization. |
| 相似性 | Belongs to the kizuna family. |
| 功能 | Centrosomal protein required for establishing a robustmitotic centrosome architecture that can endure the forces thatconverge on the centrosomes during spindle formation. Required forstabilizing the expanded pericentriolar material around thecentriole. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf19 gene product has been provisionally designated C20orf19 pending further characterization. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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