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- bs-4814R
- 2026年10月14日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4814R |
| 英文名称 | Newcastle disease virus Rabbit pAb |
| 中文名称 | 鸡新城疫疫苗（鸡瘟4型混合病毒）抗体 |
| 英文别名 | Newcastle Disease Virus Ribonucleoprotein |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Newcastle disease virus) |
| 抗体来源 | Rabbit |
| 免疫原 | whole cell protein of New Castle disease |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Organism > Virus > RNA Virus > single stranded RNA negative strand virus > Other Viruses |
| 亚基 | Homotrimer of disulfide-linked F1-F2. |
| 亚细胞定位 | Virion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| 翻译后修饰 | The inactive precursor F0 is glycosylated and proteolytically cleaved into F1 and F2 to be functionally active. The cleavage is mediated by cellular proteases during the transport and maturation of the polypeptide (By similarity). {ECO:0000250}. |
| 相似性 | Belongs to the paramyxoviruses fusion glycoprotein family. |
| 功能 | Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The entry of Newcastle disease virus (NDV), a prototype paramyxovirus, is directed by two virion glycoproteins, the hemagglutinin-neuraminidase (HN) protein and the fusion (F) protein . HN protein, the virus attachment protein, binds to sialic acid-containing receptors, and F protein mediates membrane fusion. In contrast to many viral fusion proteins, paramyxovirus F proteins do not require the acid pH of endosomes to activate fusion activity. As a consequence, infected cells expressing both attachment proteins and F proteins can fuse with adjacent cells to form multinuclear cells, or syncytia, a process that is assumed to mimic virus-cell fusion . |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验相关实验
发现于印度尼西亚的巴塔维亚，同年发现于英国新城，因此而得名。 NDV形态接近圆形。具有血凝素（HA）和神经氨酸酶(NA)，是病毒的抗原结构。NDV通过自身结构HN多肽（血凝素－神经氨酸酶）吸附到细胞上，然后病毒与细胞膜发生相互融合作用进入细胞并开始复制繁殖。 ND临床症状变化很大，与鸡群的年龄和免疫状况、感染途径及有无其它微生物并发等多种因素有关。 人也能感染新城疫，主要发生于禽类加工厂的工人、兽医和实验室工作人员在接触病毒或处理病禽时发生，潜伏期为48小时，可引起急性
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NDV | HN Rabbit pAb(bs-4814R)-50ul/100ul/200ul
￥1180 - 2800
