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- bs-7649R
- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7649R |
| 英文名称 | CIDE A Rabbit pAb |
| 中文名称 | DNA断裂因子相似蛋白A抗体 |
| 英文别名 | Cell death activator CIDE A; Cell Death Inducing DFFA Like Effector A; cell death inducing DNA fragmentation factor, alpha subunit like effector A; CIDEA; CIDEA_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Chicken, Dog, Pig, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CIDE A |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 23 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Nucleus > DNAses Cardiovascular > Heart > Apoptosis Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Metabolism Cell Biology > Apoptosis > Nucleus > DNAses Epigenetics and Nuclear Signaling > Cell cycle > Apoptosis > Nuclear Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation |
| 亚基 | Inhibited by DFFB. |
| 相似性 | Contains 1 CIDE-N domain. |
| 功能 | Activates apoptosis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICARD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B (for cell death inducing DFF like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE A is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE A is expressed in many tissues. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 5.9 }}] {Zirou Yu. et al. Different solubility dietary fibers regulate thermogenesis in rats through modulating adipose tissue activity and colonic Clostridiales. FOOD BIOSCI. 2025 Jun;68:106468} {WB} {Rat}
[IF={{ 4 }}] {Lin Liang. et al. Dietary Sea buckthorn during pregnancy reverses offspring obesity by alleviating BAT dysfunction. J FUNCT FOODS. 2025 Apr;127:106720} {WB} {Mouse}
[IF={{ 2.742 }}] {Liu, Yanrong. et al. Cinnamaldehyde affects lipid droplets metabolism after adipogenic differentiation of C2C12 cells. MOL BIOL REP. 2022 Dec;:1-7} {WB} {Mouse}
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