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- bs-6510R
- 2025年10月16日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6510R |
| 英文名称 | ABH8 Rabbit pAb |
| 中文名称 | AlkB同源蛋白8抗体 |
| 英文别名 | ABH8; alkB alkylation repair homolog 8(E. coli); alkB alkylation repair homolog 8; AlkB homologue 8; ALKB8_HUMAN; ALKBH8; Alkylated DNA repair protein alkB homolog 8; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Chicken, Dog, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ABH8/ALKBH8 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 75 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Epigenetics and Nuclear Signaling > DNA / RNA > Translation > tRNAs |
| 亚基 | Interacts with TRMT112. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Predominantlycytoplasmic. |
| 组织特异性 | Widely expressed, with highest expression inspleen, followed by pancreas and lung. |
| 相似性 | Belongs to the alkB family.
Contains 1 Fe2OG dioxygenase domain. Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | Catalyzes the methylation of 5-carboxymethyl uridine to5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in tRNA. Catalyzes the last step in the formation of5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA. Has a preference for tRNA(Arg) andtRNA(Glu), and does not bind tRNA(Lys). Required for normalsurvival after DNA damage. May inhibit apoptosis and promote cellsurvival and angiogenesis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ABH8) Polyclonal Antibody, Unconjugated (bs-6510R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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ABH8 Rabbit pAb(bs-6510R)-50ul/100ul/200ul
￥1180 - 2800
