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- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1974R |
| 英文名称 | Netrin G2 Ligand Rabbit pAb |
| 中文名称 | 脑瘤相关基因抗体 |
| 英文别名 | BAG; Brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; Leucine rich repeat containing 4; Leucine rich repeat containing protein 4; Leucine-rich repeat-containing protein 4; Lrrc4; LRRC4_HUMAN; MGC133342; MGC133343; NAG14; Nasopharyngeal carcinoma associated gene 14 protein; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin G2 ligand; Netrin-G2 ligand; NGL 2; NGL2; NGL-2; OTTHUMP00000212282; OTTHUMP00000212283; OTTHUMP00000212284. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LRRC4 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 68 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with NTNG2 (By similarity). Interacts with DLG4 (By similarity). Forms a complex with DLG4 and with NMDA receptors. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. |
| 组织特异性 | Specifically expressed in brain. |
| 相似性 | Contains 1 Ig-like (immunoglobulin-like) domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. |
| 功能 | Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitement of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 8.886 }}] {Jianbo Feng. et al. LRRC4 mediates the formation of circular RNA CD44 to inhibit GBM cell proliferation. Mol Ther-Nucl Acids. 2021 Aug;:} {WB} {Human}
[IF={{ 14.1 }}] {Yujie Shang. et al. LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells. ADV SCI. 2025 May;:2417717} {IF} {Mouse}
Theoretical Aspects of the Quantitative Characterization of Ligand Binding
dependences of the binding function ( r ) upon free ligand concentration ( C S ) for various types of acceptor‐ligand interaction. Rectangular hyperbolic dependence (—) for an acceptor with two equivalent and independent sites ( K AS = K 1 = K 2 = K 3 = K
Overview of Receptor Allosterism
, which recognizes endogenous ligands, most G protein?coupled receptors (GPCRs) possess topographically distinct allosteric sites that can be recognized by small molecules and accessory cellular proteins. Ligand binding to allosteric sites promotes a conformational
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
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