AGT | Angiotensin III (Ang III) Rabbit pAb(bs-20101R)-50ul/100ul/200ul产品图
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AGT | Angiotensin III (Ang III

) Rabbit pAb(bs-20101R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-20101R
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-20101R
    英文名称Angiotensin III Rabbit pAb
    中文名称血管紧张素III抗体
    英文别名ANGT_HUMAN; Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Ang III; Angiotensin-3; Angiotensin III; Angiotensin3; Angiotensin 3; Angiotensin-4; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 2-8; Angiotensin 3-8; Angiotensin 1-9; Angiotensin 1-10; Angiotensinogen; Serpin A8; Angiotensin IV; Ang IV; ANHU; Des-Asp[1]-angiotensin II; SERPINA8.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Horse)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide of human Angiotensin III (RVYIHPF)
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量1/50 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Cardiovascular > Blood > Serum Proteins

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    亚基During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.
    亚细胞定位Secreted.
    组织特异性Expressed by the liver and secreted in plasma.
    翻译后修饰Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
    In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
    The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
    相似性Belongs to the serpin family.
    功能Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
    Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
    Angiotensin-3: stimulates aldosterone release.
    Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料bs-0587P is a Eight branched multiple antigenic peptide of Angiotensin II.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {Flow-Cyt}{1ug/Test}

     

    产品细节图片1
    Blank control: HepG2.
    _x000D_ Primary Antibody (green line): Rabbit Anti-Angiotensin III antibody (bs-20101R)
    _x000D_ Dilution: 1μg /10^6 cells;
    _x000D_ Isotype Control Antibody (orange line): Rabbit IgG .
    _x000D_ Secondary Antibody : Goat anti-rabbit IgG-AF647
    _x000D_ Dilution: 1μg /test.
    _x000D_ Protocol
    _x000D_ The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed._x000D_
    产品细节图片2
    Sample:
    _x000D_ Lane 1: Liver (Mouse) Lysate at 40 ug
    _x000D_ Lane 2: Plasma (Mouse) at 20 ug
    _x000D_ Lane 3: Kidney (Mouse) Lysate at 40 ug
    _x000D_ Lane 4: Adrenal gland (Mouse) Lysate at 40 ug
    _x000D_ Lane 5: Adrenal gland (Rat) Lysate at 40 ug
    _x000D_ Lane 6: HepG2 (Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-Angiotensin III (bs-20101R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 52/60 kD
    _x000D_ Observed band size: 52/60 kD
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin III) Polyclonal Antibody, Unconjugated (bs-20101R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin III) Polyclonal Antibody, Unconjugated (bs-20101R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献
    [1]Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats.
    PMID:40303590Front Physiol2025-04-15
    相关实验

    • Characterization of Angiotensin II Receptors

      Abstract Table of Contents Materials Figures Literature Cited Abstract   Angiotensin II (Ang

    • 分子生物学实验基本数据

      -GCC-AGT-3' M13 (-40) universal forward 5'-GTT-TTC-CCA-GTC-ACG-AC-3' M13/pUC reverse primer 5'-CAG-GAA-ACA-GCT-ATG-ACC-3' T7 primer 5'-TAA-TAC-GAC-TCA-CTA-TAG-GG-3' SP6 primer 5'-ATT-TAG-GTG-ACA-CTA-TAG-3' -16bs 5'-TCG-AGG

    • General Reference

      and complexity of the DNA. Amino acid symbols Alanine Ala A Arginine Arg R Asparagine Asn N Aspartic acid Asp D Asparagine or Aspartic acid Asx B

    查看更多相关实验 >
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    AGT | Angiotensin III (Ang III) Rabbit pAb(bs-20101R)-50ul/100ul/200ul
    ￥1180 - 2800