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SORBS2 Rabbit pAb(bs-4905R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-4905R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-4905R
    英文名称SORBS2 Rabbit pAb
    中文名称精氨酸结合蛋白2抗体
    英文别名ArgBP2; Arg binding protein 2; Arg/Abl interacting protein 2; Arg/Abl interacting protein; ARGBP2; PRO0618; SRBS2_HUMAN; sorbin and SH3 domain containing 2.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Rat (Human, Mouse, Chicken, Dog, Pig, Horse, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SORBS2/ArgBP2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量124 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Protein Phosphorylation > Tyrosine Kinases

    亚基Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin, and WASF (By similarity). Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD and PAK1.
    亚细胞定位Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion.
    组织特异性Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells.
    翻译后修饰Ubiquitinated by CBL.
    相似性Contains 3 SH3 domains.
    Contains 1 SoHo domain.
    功能Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料SORBS2 is an adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. It can form a complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SORBS2) Polyclonal Antibody, Unconjugated (bs-4905R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    该产品被引用文献

    [IF={{ 9.452 }}] {Tong,et al.HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.(2018) Biochimica Et Biophysica Acta. 1864:1104-1114.} {WB} {Human}

    [IF={{ 5.542 }}] {Han L et al. The RNA‐binding protein SORBS2 suppresses hepatocellular carcinoma tumorigenesis and metastasis by stabilizing RORA mRNA. Liver Int. 2019 Jul 31.} {IHC} {Human}

    [IF={{ 4.6 }}] {Beibei Wang. et al. The RNA-binding protein sorbin and SH3 domain-containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor. MOL CARCINOGEN. 2024 Mar;:} {IHC} {Mouse}

    [IF={{ 2.8 }}] {Yue Deng. et al. ARID5B promoted the histone demethylation of SORBS2 and hampered the metastasis of ovarian cancer. PATHOL RES PRACT. 2023 Dec;252:154911} {WB,IHC} {Mouse,Human}

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    文献支持
    SORBS2 Rabbit pAb(bs-4905R)-50ul/100ul/200ul
    ￥1180 - 2800