Blank control(blue): Hep G2 cells(fixed with 2% Paraformaldehyde (10 min)).
Primary Antibody: Rabbit Anti-Tap1/FITC Conjugated antibody (bs-2789R/FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.
- ￥1180 - 2800
- Bioss
- bs-2789R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2789R |
| 英文名称 | Tap1 Rabbit pAb |
| 中文名称 | ATP结合转运因子1抗体 |
| 英文别名 | ABC transporter MHC 1; ABC17; ABCB 2; ABCB2; Antigen peptide transporter 1; APT 1; APT1; ATP binding cassette sub family B(MDR/TAP) member 2; ATP binding cassette sub family B member 2; ATP binding cassette transporter; D6S114E; FLJ26666; FLJ41500; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF 1; Peptide transporter PSF1; Peptide transporter TAP 1; Peptide transporter TAP1; PSF 1; PSF1; RING 4; RING4; TAP 1; TAP1*0102N; TAP1N; Transporter 1 ATP binding cassette sub family B(MDR/TAP); Transporter 1 ATP binding cassette sub family B; Transporter 1 ATP Binding Cassette Sub-Family B; Transporter associated with antigen processing; Transporter ATP binding cassette major histocompatibility complex 1; Y3; TAP1_HUMAN. |
| 产品应用 | Flow-Cyt=1μg /Test Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Tap1/ABCB2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 87 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > Translesion Synthesis |
| 亚基 | Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barrvirus BNLF2a. Interacts with PSMB5 and PSMB8. |
| 亚细胞定位 | Endoplasmic reticulum membrane; Multi-passmembrane protein. Note=The transmembrane segments seem to form apore in the membrane. |
| 相似性 | Belongs to the ABC transporter superfamily. ABCBfamily. MHC peptide exporter (TC 3.A.1.209) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. |
| 功能 | Involved in the transport of antigens from the cytoplasmto the endoplasmic reticulum for association with MHC class Imolecules. Also acts as a molecular scaffold for the final stage ofMHC class I folding, namely the binding of peptide. Nascent MHCclass I molecules associate with TAP via tapasin. Inhibited by thecovalent attachment of herpes simplex virus ICP47 protein, whichblocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal sideof the TAP complex and inhibits peptide translocation byspecifically blocking ATP-binding to TAP1 and prevents theconformational rearrangement of TAP induced by peptide binding.Inhibited by human adenovirus E3-19K glycoprotein, which binds theTAP complex and acts as a tapasin inhibitor, preventing MHC classI/TAP association. Expression of TAP1 is down-regulated by humanEpstein-Barr virus vIL-10 protein, thereby affecting the transportof peptides into the endoplasmic reticulum and subsequent peptideloading by MHC class I molecules. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /Test} |
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文献和实验该产品被引用文献
[IF={{ 4.35 }}] {Stettner, Mark, et al. "Interleukin-17 impedes Schwann cell-mediated myelination." Journal of Neuroinflammation 11.1 (2014): 63.} {Other} {="Mouse"}
[IF={{ 24.1 }}] {Lei Xin. et al. CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors. CELL MOL IMMUNOL. 2024 Feb;:1-19} {FCM} {Human}
[IF={{ 2.657 }}] {Deng S et al. Host cell protein PSMB10 interacts with viral NS3 protein and inhibits the growth of classical swine fever virus. Virology. 2019 Aug 23;537:74-83.} {WB} {Pig}
[IF={{ 17.694 }}] {Lei, Xin. et al. CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment. NAT COMMUN. 2023 Jan;14(1):1-14} {FCM} {Human}
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Tap1 Rabbit pAb(bs-2789R)-50ul/100ul/200ul
￥1180 - 2800
