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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-15492R |
| 英文名称 | LOX Rabbit pAb |
| 中文名称 | 蛋白赖氨酸-6-氧化酶抗体 |
| 英文别名 | LYOX_HUMAN; Protein-lysine 6-oxidase; EC:1.4.3.13; Lysyl oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form; AAT10; |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LOX |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 29 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment Cardiovascular > Vasculature > Endothelium Cardiovascular > Vasculature > Smooth muscle cell (SMC) > Extracellular matrix Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes |
| 亚细胞定位 | Secreted; extracellular space |
| 组织特异性 | Heart, placenta, skeletal muscle, kidney, lung and pancreas. |
| 翻译后修饰 | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). |
| 相似性 | Belongs to the lysyl oxidase family. |
| 功能 | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 5.064 }}] {Xia Liu. et al. The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway. Acta Pharmacol Sin. 2021 Apr;:1-9} {WB,IF} {Mouse}
[IF={{ 4.145 }}] {Runze Zhao. et al. Nucleus pulposus cell senescence is regulated by substrate stiffness and is alleviated by LOX possibly through the integrin β1-p38 MAPK signaling pathway. EXP CELL RES. 2022 Aug;417:113230} {WB} {Rat}
[IF={{ 3.647 }}] {Runze Zhao. et al. Lysyl oxidase inhibits TNF-α induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways. Life Sci. 2020 Nov;260:118483} {WB} {Rat}
OLR1（LOX-1）配体结合机制、胞内信号调控及蛋白试剂应用解析
。此外，OLR1在多种免疫及特定功能细胞中也广泛存在，包括单核吞噬细胞、中性粒细胞、树突状细胞、滋养层细胞以及胶质细胞。这种广泛的分布模式提示OLR1不仅在血管生物学中发挥作用，还深度参与了免疫调节及神经系统的生理过程。 OLR1的结构和其受体 OLR1（又称LOX-1）是一种属于C型凝集素超家族的II型跨膜糖蛋白，分子量约50-52 kDa，由273个氨基酸组成。其结构主要包含三个部分：N端的短胞质尾区、跨膜结构域以及C端的胞外凝集素样结构域，后者是识别配体的关键区域。作为受体，OLR1的主要配体是氧
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
mTn-3xHA/lacZ TR Tn3 terminal inverted repeats Xa Factor Xa cleavage recognition site loxR lox site, target for Cre recombinase
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