Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- FOX C2 (bs-8730R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size:53 kD
- ￥1180 - 2800
- Bioss
- bs-8730R
- 2025年10月24日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8730R |
| 英文名称 | FOX C2 Rabbit pAb |
| 中文名称 | 叉头相关转录因子C2抗体 |
| 英文别名 | Drosphilia Forkhead Homolog Like 14; Drosphilia Forkhead Homolog Like 14; FKHL 14; FKHL 14; FKHL14; Forkhead Box C2; Forkhead Box C2; Forkhead box protein C2; Forkhead related protein FKHL14; Forkhead-related protein FKHL14; FOX C2; Foxc2; FOXC2_HUMAN; LD; Mesenchyme fork head protein 1; Mesenchyme Forkhead 1; Mesenchyme Forkhead 1; MFH 1; MFH 1; MFH 1 protein; MFH-1 protein; MFH1; Transcription factor FKH 14; Transcription factor FKH-14. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Chicken, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FOX C2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 53 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Organogenesis > Excretory system development > Kidney development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Forkhead Box Epigenetics and Nuclear Signaling > Transcription > Domain Families > Forkhead Box > FOXC Metabolism > Types of disease > Metabolic disorders |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 fork-head DNA-binding domain. |
| 功能 | Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3). FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4). Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4). FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3). FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3). FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2). |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 7.9 }}] {Tiantian Ye. et al. Borneol regulates meningeal lymphatic valve plasticity to clear Aβ aggregates in the prevention of AD-like symptoms. PHYTOMEDICINE. 2024 May;:155753} {IF,WB} {Mouse}
[IF={{ 4.7 }}] {Yudong Wang. et al.Modulation of the Epithelial–mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury.respiratory research.2025 Mar 10;26(1):96.} {IHC} {Mouse}
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FOX C2 Rabbit pAb(bs-8730R)-50ul/100ul/200ul
￥1180 - 2800
