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- Bioss
- bs-4595R-BF680
- 2025年09月30日
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100ul
| 产品编号 | bs-4595R-BF680 |
| 英文名称 | Collagen IV Rabbit pAb, BF680 conjugated |
| 中文名称 | BF680标记的IV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体 |
| 英文别名 | Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; Collagen alpha 1(IV) Chain; Collagen IV alpha 1 Polypeptide; Collagen Of Basement Membrane alpha 1 Chain; Collagen Of Basement Membrane alpha 2 Chain; Collagen Type IV alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4A1 NC1 domain; CO4A1_HUMAN; Collagen Ⅳ; Collagen Type Ⅳ. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix, basement membrane. |
| 组织特异性 | Highly expressed in placenta. |
| 翻译后修饰 | Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates._x000D_
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains._x000D_ Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens._x000D_ The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues._x000D_ Proteolytic processing produces the C-terminal NC1 peptide, arresten. |
| 相似性 | Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. |
| 功能 | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen._x000D_
Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Collagen IV Rabbit pAb, BF680 conjugated(bs-4595R-BF680)-100ul
￥2980
