- ￥1180 - 2800
- Bioss
- bs-13005R
- 2025年10月17日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
phospho-VEGFR2 (Tyr1175) Rabbit pAb, PE-Cy5 conjugated(bs-3468R-PE-Cy5)-100ul
￥2980
DACT3 Rabbit pAb(bs-11837R)-50ul/100ul/200ul
￥1180GABA A receptor pi Rabbit pAb, HRP conjugated(bs-13257R-HRP)-100ul
￥2980
phospho-TEM8 (Tyr382) Rabbit pAb(bs-5210R)-50ul/100ul/200ul
￥1180PTEN Mouse mAb, PerCP-Cy5.5 conjugated(bsm-33320M-PerCP-Cy5.5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-13005R |
| 英文名称 | DKK2 Rabbit pAb |
| 中文名称 | DKK2抗体 |
| 英文别名 | Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DKK2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 25 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Stem Cells > Signaling Pathways > Wnt > Secreted |
| 亚基 | Interacts with LRP5 and LRP6. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed in heart, brain, skeletal muscle and lung. |
| 翻译后修饰 | May be proteolytically processed by a furin-like protease. |
| 相似性 | Belongs to the dickkopf family. |
| 功能 | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
[IF={{ 5.011 }}] {Juanjuan Li. et al. The effect of 1,25-dihydroxyvitamin D3 on the Wnt signaling pathway in bovine intestinal epithelial cells is mediated by the DKK2 (dickkopf2) Wnt antagonist. J STEROID BIOCHEM. 2023 Jul;231:106319} {WB} {Bovine}
技术资料暂无技术资料 索取技术资料
文献支持
DKK2 Rabbit pAb(bs-13005R)-50ul/100ul/200ul
￥1180 - 2800
