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- bs-11531R
- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11531R |
| 英文名称 | NPW/Neuropeptide W Rabbit pAb |
| 中文名称 | 神经肽W抗体 |
| 英文别名 | hPPL8; L8; L8C; Neuropeptide W; PPL8; PPNPW; Preproprotein L8; NPW_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Neuropeptide W |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 3 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Secreted |
| 组织特异性 | Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma. |
| 相似性 | Belongs to the neuropeptide B/W family. |
| 功能 | NPW is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NPW is a 165 amino acid secreted protein that is cleaved into two chains: neuropeptide W-23 (also designated NPW23 or L8) and neuropeptide W-30 (also known as NPW30 or L8C). Both NPW neuropeptides activate G-protein coupled receptors in the central nervous system to enhance cortisol secretion. Highly expressed in lymphoblastic leukemia, colorectal adenocarcinoma, fetal kidney, trachea and substantia nigra, NPW is also found at low levels in placenta, ovary, testis and uterus. NPW functions in organization of neuroendocrine signals and is also thought to enhance food and water intake as well as stress responses. The gene encoding NPW maps to human chromosome 16p13.3. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 6.8 }}] {Ye Jiazhou. et al. Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma. NPJ PRECIS ONCOL. 2024 Nov;8(1):1-18} {IHC} {Human}
[IF={{ 6.208 }}] {Shashank Pandey. et al. Regulation of Prepro-NeuropeptideW/B and Its Receptor in the Heart of ZDF Rats: An Animal Model of Type II DM. INT J MOL SCI. 2022 Jan;23(23):15219} {WB} {Rat}
[IF={{ 4.556 }}] {Shashank Pandey. et al. Identification of NPB, NPW and Their Receptor in the Rat Heart. Int J Mol Sci. 2020 Jan;21(21):7827} {WB,IF} {Rat}
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