Sample:
Jurkat (Human) Lysate at 40 ug
Primary: Anti- TBX1 (bs-11216R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 35 kD
- ￥1180 - 2800
- Bioss
- bs-11216R
- 2025年10月16日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11216R |
| 英文名称 | Sprouty1 Rabbit pAb |
| 中文名称 | 软脂酰化磷蛋白Sprouty1抗体 |
| 英文别名 | Sprouty 1; Sprouty-1; hSPRY1; Protein sprouty homolog 1; Sprouty homolog 1 antagonist of FGF signaling; Sprouty homolog 1; Spry-1; Spry1; SPY1_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Sprouty1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 35 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Growth Factors/Hormones > FGF |
| 亚基 | Belongs to the sprouty family. Contains 1 SPR (sprouty) domain. |
| 亚细胞定位 | Cellular localizationCytoplasm. Membrane. Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF. |
| 相似性 | Belongs to the sprouty family. Contains 1 SPR (sprouty) domain. |
| 功能 | May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich C-terminal domain with their Drosophila counterparts. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane. Sprouty 2 can associate with c-Cbl, a down regulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The well-conserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 co-localization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 7.051 }}] {Shi Tiezhu. et al. Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis. CELL ONCOL. 2023 Apr;:1-17} {IHC} {Mouse}
[IF={{ 4.6 }}] {Xingyu Fang. et al. Possible involvement of a MEG3-miR-21-SPRY1-NF-κB feedback loop in spermatogenic cells proliferation, autophagy and apoptosis. ISCIENCE. 2024 九月 09} {WB} {Human}
[IF={{ 2.3 }}] {Bo Qiu. et al. Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms. J COSMET DERMATOL-US. 2023 Dec;:} {WB} {Human}
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Sprouty1 Rabbit pAb(bs-11216R)-50ul/100ul/200ul
￥1180 - 2800
