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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8612R |
| 英文名称 | GPR70 Rabbit pAb |
| 中文名称 | G蛋白偶联受体70抗体 |
| 英文别名 | GPCR TAS1R1; G protein coupled receptor 70; G-protein coupled receptor 70; gm 148; gm148; GPR 70; GPR70; Krueppel related zinc finger protein 3(HKR3 protein); Sweet taste receptor T1r; T1R1; TAS1 R1; TAS1R1; Taste receptor type 1 member 1; TR 1; TR1; TS1R1_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GPR70/T1R1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 90 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Forms heterodimers with TAS1R3. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. |
| 功能 | Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 9.8 }}] {Minbo Li. et al. A novel strategy based on mouse organoid biosensor for detecting umami substances and their synergistic effect. FOOD CHEM. 2025 Jun;:145149} {IF} {Mouse}
[IF={{ 4.55 }}] {Liu, Junqiang, et al. "Milk protein synthesis is regulated by T1R1/T1R3, a G protein‐coupled taste receptor, through the mTOR pathway in the mouse mammary gland." Molecular Nutrition & Food Research (2017).} {IHC} {="Mouse"}
[IF={{ 2.614 }}] {Cuicui Kanget al. l‐Glutamate stimulates cholecystokinin secretion via the T1R1/T1R3 mediated PLC/TRPM5 transduction pathway. J Sci Food Agric . 2020 Oct;100(13):4818-4825.} {WB} {pig}
[IF={{ 12.6 }}] {Yuxia Fan. et al. Umami taste evaluation based on a novel mouse taste receptor cell-based biosensor. BIOSENS BIOELECTRON. 2023 Jun;:115447} {IHC,WB} {Mouse,Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
resistance 3.PAB 与氟康唑联合应用对生物膜形成的抑制效果经 XTT 法测定药物联用对热带念珠菌生物膜活性的抑制效果，发现 PAB 与氟康唑联用时对早期、发展期及成熟期生物膜均有较好抑制效果。氟康唑本身对成熟生物膜的抑制作用较弱，但当一定浓度 PAB 存在时，随着氟康唑药物浓度的升高，对生物膜的抑制率也逐渐升高。二者联用，在 64 μg/mL PAB 条件下，2、32、256 μg/mL 氟康唑对成熟生物膜的抑制率分别为 50%、70%、 80%。 图片来源：Infection and drug
抗体型和固相抗原型ELISA。A.固相抗体型ELISA：将抗激素的单克隆抗体（Mab）与已吸附于固相载体上的兔抗鼠Ig抗体（RAMIG）结合，然后加入激素标准品或待测样品，使其与固相化的Mab结合， 再加入辣根过氧化物酶（HRP）标记激素（酶标激素）。通过测定酶标激素的被结合量，可换算出未知样品中激素的数量。B.固相抗原型ELISA：将“激素-蛋白”复合物（该蛋白应不同于免疫原中的载体蛋白）包被于固相载体，加入待测激素（样品或标准品）和抗IAA多克隆抗体（Pab）反应，进行竞争反应。然后让HRP
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