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- bs-10023R
- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-10023R |
| 英文名称 | STAT4 Rabbit pAb |
| 中文名称 | 信号转导和转录激活因子4抗体 |
| 英文别名 | signal transducers and activators of transduction 4; CIS4; HSPC060; SOCS4; SOCS6; SSI4; STAI4; STAT 4; STAT4; STATI4; Suppressor of cytokine signaling 6; STAT4_HUMAN. |
| 产品应用 | WB=1:500-2000, ICC/IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human STAT4 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 85 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Nuclear signaling > STAT family Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Epigenetics and Nuclear Signaling > Transcription > Other factors Kits/ Lysates/ Other > Kits > ELISA Kits > In Cell ELISA Kits > Phosphoprotein ICE kits Signal Transduction > Signaling Pathway > Nuclear Signaling > STATs |
| 亚基 | Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP. The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. |
| 翻译后修饰 | Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity. |
| 相似性 | Belongs to the transcription factor STAT family. Contains 1 SH2 domain. |
| 功能 | Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ICC/IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 7.9 }}] {Tiantian Wang. et al. Baicalein alleviates cardiomyocyte death in EAM mice by inhibiting the JAK-STAT1/4 signalling pathway. PHYTOMEDICINE. 2024 Jun;128:155558} {WB,IF} {Mouse}
[IF={{ 5.714 }}] {Chenglin Li. et al. Ranitidine as an adjuvant regulates macrophage polarization and activates CTLs through the PI3K-Akt2 signaling pathway. INT IMMUNOPHARMACOL. 2023 Mar;116:109729} {WB} {Mouse}
[IF={{ 5.7 }}] {Xixi Wang. et al. Probing Selenium-Deficient Chicken Spleen Th1/Th17 Differentiation Based on Selenoprotein W Targeting of PKM2/HIF1α. J AGR FOOD CHEM. 2024;XXXX(XXX):XXX-XXX} {WB} {Chicken}
[IF={{ 3.943 }}] {Le Tian. et al. Luteolin as an adjuvant effectively enhances CTL anti-tumor response in B16F10 mouse model. Int Immunopharmacol. 2021 May;94:107441} {WB} {Mouse}
[IF={{ 3.487 }}] {Ran Lu. et al. Chrysin Enhances Anti-tumor Immunity Response through IL-12-STAT4 Signal Pathway in B16F10 Melanoma Mouse Model. SCAND J IMMUNOL. 2022 Apr 28} {WB} {Mouse}
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