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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6305R |
| 英文名称 | Ryanodine Receptor Rabbit pAb |
| 中文名称 | 心肌兰尼碱受体抗体（脑肌兰尼碱受体） |
| 英文别名 | RYR1_HUMAN; Arrhythmogenic right ventricular dysplasia 2; ARVC 2; ARVC2; ARVD 2; ARVD2; Brain ryanodine receptor calcium release channel; Brain type ryanodine receptor; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor calcium release channel; Cardiac muscle type ryanodine receptor; CCO; Central core disease of muscle; HBRR; hRYR 2; hRYR2; MHS; MHS1; Ryanodine receptor 1(skeletal); Ryanodine receptor 1; Ryanodine receptor 2(cardiac); Ryanodine receptor 2; Ryanodine receptor 3; Ryanodine receptor type1; RYDR; RYR 1; RYR 2; RYR 3; RYR; RYR1; RYR2; RYR3; Sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; SKRR; Type 1 like ryanodine receptor; VTSIP. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Dog, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Ryanodine Receptor |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 566 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Homotetramer. Can also form heterotetramers with RYR2.Interacts with CALM; CALM with bound calcium inhibits the RYR1channel activity. Interacts with S100A1. Interacts with FKBP1A;this stabilizes the closed conformation of the channel. Interactswith CACNA1S; interaction with CACNA1S is important for activationof the RYR1 channel. Interacts with CACNB1. Interacts with TRDN andASPH; these interactions stimulate RYR1 channel activity (Bysimilarity). Identified in a complex composed of RYR1, PDE4D, PKA,FKBP1A and protein phosphatase 1 (PP1). Repeated very high-levelexercise decreases interaction with PDE4D and protein phosphatase 1(PP1). |
| 亚细胞定位 | Sarcoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. |
| 组织特异性 | Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus. |
| 翻译后修饰 | Channel activity is modulated by phosphorylation.Phosphorylation at Ser-2843 may increase channel activity. Repeatedvery high-level exercise increases phosphorylation at Ser-2843.[PTM] Activated by reversible S-nitrosylation. Repeated veryhigh-level exercise increases S-nitrosylation. |
| 相似性 | Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily. Contains 3 B30.2/SPRY domains. Contains 5 MIR domains. |
| 功能 | Calcium channel that mediates the release of Ca(2+) fromthe sarcoplasmic reticulum into the cytoplasm and thereby plays akey role in triggering muscle contraction following depolarizationof T-tubules. Repeated very high-level exercise increases the openprobability of the channel and leads to Ca(2+) leaking into thecytoplasm. Can also mediate the release of Ca(2+) fromintracellular stores in neurons, and may thereby promote prolongedCa(2+) signaling in the brain. Required for normal embryonicdevelopment of muscle fibers and skeletal muscle. Required fornormal heart morphogenesis, skin development and ossificationduring embryogenesis (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ryanodine Receptor) Polyclonal Antibody, Unconjugated (bs-6305R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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文献和实验该产品被引用文献
[IF={{ 2.466 }}] {Gerburg Keilhoff. et al. The Ryanodine receptor stabilizer S107 fails to support motor neuronal neuritogenesis in vitro. Tissue Cell. 2021 Dec;73:101625} {IF} {Mouse}
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has been identified as a high-affinity receptor for the plant alkaloid ryanodine, and purified to apparent homogeneity as a 30s protein complex comprising four identical high- mol-wt polypeptide subunits of relative mol mass (M r ) ~560,000 (it1
secondary antibody review -- data from 99 publications
data
, Algermissen, B. et al. 3. Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine Sepharose 6B. J. Chromatogr. (1989), 475 363-72, Stell, J. G. P. et al. 4. The Crystal Structure of a T Cell Receptor in Complex
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Ryanodine Receptor Rabbit pAb(bs-6305R)-50ul/100ul/200ul
￥1180 - 2800
