HECW1 | NEDL1 Rabbit pAb(bs-11692R)-50ul/100ul/200ul产品图

HECW1 | NEDL1 Rabbit pAb(bs-11

692R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-11692R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-11692R
    英文名称HECW1 Rabbit pAb
    中文名称肌萎缩侧索硬化症相关蛋白HECW1抗体
    英文别名NEDL1; C2 and WW domain-containing protein 1; E3 ubiquitin-protein ligase HECW1; HECT; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECW 1; Hecw1; HECW1_HUMAN; hNEDL1; NEDD4 like ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase 1; NEDL-1; NEDL 1.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Rat (Human, Mouse, Cow, Chicken, Dog)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human HECW1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量179 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Apoptosis > Intracellular > p53 Pathway

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Hect E3 Ligase

    Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > E3 Ubiquitin Ligases

    Neuroscience > Neurology process > Neurodegenerative disease > Amyotrophic lateral sclerosis

    亚基Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.
    亚细胞定位Cytoplasm.
    组织特异性Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
    相似性Contains 1 C2 domain.
    _x000D_ Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    _x000D_ Contains 2 WW domains.
    功能E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料NEDL1 is a 1,606 amino acid cytoplasmic protein predominantly expressed in neurons of adult and fetal brain. NEDL1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. NEDL1 mediates ubiquitination and subsequent degradation of Dvl-1 and targets mutant SOD-1. NEDL1 forms cytotoxic aggregates with Dvl, TRAP-?and mutant SOD1 that lead to motor neuron death in FALS (familial amyotrophic lateral sclerosis). individuals affect by FALS (also known as Lou Gehrig's disease) experience muscle weakness and atrophy throughout the body. FALS is caused by the degeneration of upper and lower motor neurons resulting in loss of signal to muscles.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Tissue/cell: rat brain tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    _x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    _x000D_ Incubation: Anti-HECW1 Polyclonal Antibody, Unconjugated(bs-11692R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    _x000D_ _x000D_

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