Sample:
Lane 1: Human HepG2 cell lysates
Lane 2: Human HeLa cell lysates
Primary: Anti-CCBR1 (bs-6883R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kDa
Observed band size: 57 kDa
- ￥1180 - 1980
- Bioss
- bs-6883R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-6883R |
| 英文名称 | CCBR1 Rabbit pAb |
| 中文名称 | 钙离子通道阻端耐药蛋白CCBR1抗体 |
| 英文别名 | Amino acid transport system xc xCT antibody; Amino acid transport system xc-antibody Calcium channel blocker resistance protein CCBR1; Calcium channel blocker resistance protein CCBR1 antibody; CCBR1; Cysteine/glutamate transporter antibody; cystine/glutamate transporter; SLC7A11; Solute carrier family 7(anionic amino acid transporter light chain, xc-system), member 11; solute carrier family 7; Solute carrier family 7 member 11; Solute carrier family 7, (cationic amino acid transporter, y+system) member 11; xCT; XCT_HUMAN. |
| 产品应用 | WB=1:500-1000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human xCT/CCBR1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 55 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity). |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 相似性 | Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. |
| 功能 | Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-1000} |
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文献和实验该产品被引用文献
[IF={{ 8.2 }}] {Jiajia Yang. et al. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius. INT J BIOL MACROMOL. 2024 Mar;:130703} {WB} {Mouse}
[IF={{ 7.5 }}] {Shengting Wu. et al. ADSC-Exos enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the NRF2/SLC7A11/GPX4 pathway. BIOMED PHARMACOTHER. 2024 Mar;172:116225} {WB} {Rat,Human}
[IF={{ 7.31 }}] {Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555} {WB,IP} {Mouse,Human}
[IF={{ 6.7 }}] {Siqi Li. et al.Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation..PHYTOMEDICINE.2025 Mar 16:141:156642.} {Western blot} {Human}
[IF={{ 6.244 }}] {Li Y. et al. Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells.. Front Oncol. 2022 Mar;12:693395-693395} {WB} {Mouse,Human}
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CCBR1 Rabbit pAb(bs-6883R)-50ul/100ul
￥1180 - 1980
