Sample:
_x000D_
Lane 1: Human Jurkat cell lysates
_x000D_
Lane 2: Human HeLa cell lysates
_x000D_
Lane 3: Human K562 cell lysates
_x000D_
Lane 4: Human HL-60 cell lysates
_x000D_
Primary: Anti-SRRM1 (bs-8066R) at 1/1000 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 102 kDa
_x000D_
Observed band size: 120 kDa
- ￥1180 - 2800
- Bioss
- bs-8066R
- 2026年10月13日
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- 技术资料
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8066R |
| 英文名称 | SRRM1 Rabbit pAb |
| 中文名称 | 丝氨酸/精氨酸相关核基质蛋白1抗体 |
| 英文别名 | Ser/Arg related nuclear matrix protein; Ser/Arg-related nuclear matrix protein; Serine/arginine repetitive matrix protein 1; SR related nuclear matrix protein of 160 kDa; SR-related nuclear matrix protein of 160 kDa; SRm160; Srrm1; SRRM1_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SRRM1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 102 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing |
| 亚基 | Identified in the spliceosome C complex. Found in apre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE)complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Found in amRNA splicing-dependent exon junction complex (EJC) with DEK,PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts withBAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compoundof RNA export complexes that are released from speckles in aATP-dependent manner. |
| 亚细胞定位 | Nucleus matrix. Nucleus speckle. |
| 相似性 | Belongs to the splicing factor SR family. Contains 1 PWI domain._x000D_ |
| 功能 | Part of pre- and post-splicing multiprotein mRNPcomplexes. Involved in numerous pre-mRNA processing events.Promotes constitutive and exonic splicing enhancer (ESE)-dependentsplicing activation by bridging together sequence-specific (SRfamily proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP(SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA3'-end cleavage independently of the formation of an exon junctioncomplex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream ofexon-exon junctions. Binds RNA and DNA with low sequencespecificity and has similar preference for either double- orsingle-stranded nucleic acid substrates. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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SRRM1 | SRM160 Rabbit pAb(bs-8066R)-50ul/100ul/200ul
￥1180 - 2800
