GFR alpha 3 Rabbit pAb(bs-11501R)-50ul/100ul/200ul

GFR alpha 3 Rabbit pAb(bs-1150

1R)-50ul/100ul/200ul
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  • ¥1180 - 2800
  • Bioss已认证
  • bs-11501R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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    • 规格

      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-11501R
    英文名称GFR alpha 3 Rabbit pAb
    中文名称GDNF家族受体α3抗体 GFR α3
    英文别名GFRA3; GDNF family receptor alpha 3; GDNF Receptor alpha 3; GFR alpha 3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3; GFRA3_HUMAN; Glial cell line derived neurotrophic factor receptor alpha 3; GPI linked receptor.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat (Human)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human GFR alpha 3
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量38 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚细胞定位Cell membrane.
    组织特异性Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
    翻译后修饰N-glycosylated.
    相似性Belongs to the GDNFR family.
    功能Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF Beta superfamily of growth factors. Three receptors for these factors, GFR Alpha-1 (also designated GDNFR-Alpha, RETL1 or TrnR-1), GFR Alpha-2 (also designated GDNFR-Beta, RETL2, NTNR-Alpha or TrnR-2) and GFR Alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR Alpha-1 and GFR Alpha-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR Alpha-3 is expressed only during development.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    GFR alpha 3 Rabbit pAb(bs-1150
    Sample:
    Lane 1: Mouse Heart tissue lysates
    Lane 2: Mouse Stomach tissue lysates
    Lane 3: Rat Spleen tissue lysates
    Lane 4: Rat Stomach tissue lysates
    Primary: Anti-GFR alpha 3 (bs-11501R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 38 kDa
    Observed band size: 42 kDa

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