Sample:
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Jurkat(Human) Cell Lysate at 30 ug
_x000D_
K562(Human) Cell Lysate at 30 ug
_x000D_
Primary: Anti-phospho-DOK1(Tyr362) (bs-5289R) at 1/1000 dilution
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Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
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Predicted band size: 62 kD
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Observed band size: 62 kD
- ￥1180 - 2800
- Bioss
- bs-5289R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-5289R |
| 英文名称 | phospho-DOK1 (Tyr362) Rabbit pAb |
| 中文名称 | 磷酸化D酪氨酸激酶衰减蛋白1抗体 |
| 英文别名 | DOK1(phospho Y362); DOK1(phospho Tyr362); p-DOK1(phospho Y362); docking protein 1(downstream of tyrosine kinase 1); Docking protein 1(p62(dok))(Downstream of tyrosine kinase 1)(pp62).; docking protein 1 62kD(downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Pig, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 62 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction Cancer > Signal transduction > Protein phosphorylation Cardiovascular > Blood > Platelets Metabolism > Types of disease > Obesity Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Protein Phosphorylation > Tyrosine Kinases Signal Transduction > Signaling Pathway > Lipid Signaling |
| 亚基 | Interacts with ABL1. Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. |
| 亚细胞定位 | Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region. |
| 组织特异性 | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. |
| 翻译后修饰 | Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Isoform 3 contains a N-acetylmethionine at position 1. |
| 相似性 | Belongs to the DOK family. Type A subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
| 功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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DOK1 (p-Y362) Rabbit pAb(bs-5289R)-50ul/100ul/200ul
￥1180 - 2800
