Sample:HepG2 (Human)cell Lysate at 40 ug
Primary: Anti-PCDH8(bs-11114R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 110kD
Observed band size: 110kD
- ￥1180 - 2800
- Bioss
- bs-11114R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11114R |
| 英文名称 | PCDH8 Rabbit pAb |
| 中文名称 | 原钙粘附蛋白8抗体 |
| 英文别名 | Arcadlin; PAPC; PCDH 8; Protocadherin 8; Protocadherin8; PCDH8_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Pig, Cow, Rabbit, Goose, Sheep, Chimpanzee) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PCDH8 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 110 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > Membrane Proteins Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cadherins |
| 亚基 | The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis (By similarity). Interacts with CDH2; this interaction may lead to CDH2 cointernalization (By similarity). Interacts with CDH11 (By similarity). Interacts with TAOK2 (By similarity). |
| 亚细胞定位 | Cell Membrane. Single-pass type I membrane protein. |
| 相似性 | Contains 6 cadherin domains. |
| 功能 | PCDH8 (Protocadherin 8) belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. It is thought to function in cell-adhesion in a calcium-dependent manner. It is predominantly expressed in brain, localizing to synaptic junctions. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH8 (protocadherin-8), also known as Arcadlin or PAPC, is a 1,070 amino acid single-pass type I membrane protein that contains six cadherin domains and belongs to the protocadherin family. Localized to the cell membrane and expressed specifically in fetal and adult brain, PCDH8 is thought to play a role in cell adhesion events in the central nervous system (CNS). PCDH8 is inactivated or silenced in breast cancer, suggesting a possible role in tumor suppression. Two isoforms of PCDH8 that differ in their cytoplasmic tails are expressed due to alternative splicing events. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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PCDH8 Rabbit pAb(bs-11114R)-50ul/100ul/200ul
￥1180 - 2800
