Sample: heart (mouse) Lysate at 40 ug
Primary: Anti- ITLN1(bs-5129R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35kD
Observed band size: 35kD
- ￥1180 - 2800
- Bioss
- bs-5129R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-5129R |
| 英文名称 | ITLN1 Rabbit pAb |
| 中文名称 | 内皮细胞凝集素HL1抗体 |
| 英文别名 | Endothelial lectin HL 1; Endothelial lectin HL-1; Galactofuranose binding lectin; Galactofuranose-binding lectin; hIntL; HL 1; HL1; Intelectin; Intelectin 1; Intelectin-1; Intestinal lactoferrin receptor; INTL; ITLN; ITLN-1; ITLN1; ITLN1_HUMAN; LFR; Omentin. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ITLN1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 35 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood Cardiovascular > Lipids / Lipoproteins > Adipose Related > Acrp Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Homotrimer; disulfide-linked. |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. |
| 组织特异性 | Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 1 fibrinogen C-terminal domain. |
| 功能 | Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Obesity and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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[IF={{ 6.6 }}] {Xiaoran Fu. et al. The Effect of Mineralocorticoid Receptor 3 Antagonists on Anti-Inflammatory and Anti-Fatty Acid Transport Profile in Patients with Heart Failure. CELLS-BASEL. Cells-Basel. 2022 Jan;11(8):1264} {IHC} {Human}
[IF={{ 4.87 }}] {Liu H et al. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP‐induced Parkinson's disease in mice. J Neurochem. 2019 Aug 23.} {IHC,WB} {Mouse}
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ITLN1 Rabbit pAb(bs-5129R)-50ul/100ul/200ul
￥1180 - 2800
