Sample:
Lane 1: Mouse Testis Lysates
Lane 2: Mouse Spleen Lysates
Lane 3: Rat Testis Lysates
Lane 4: Rat Spleen Lysates
Lane 5: Human U-87 MG cell Lysates
Lane 6: Human DU145 cell Lysates
Primary: Anti-HAS1 (bs-2946R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65kDa
Observed band size: 65kDa
- ￥1180 - 2800
- Bioss
- bs-2946R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/200ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-2946R |
| 英文名称 | HAS1 Rabbit pAb |
| 中文名称 | 透明质酸合成酶1抗体 |
| 英文别名 | HA synthase 1; HAS; HAS1; HAS 1; HAS-1; HAS1_HUMAN; HuHAS1; Hyaluronan synthase 1; Hyaluronan synthase; HA Synthase: Hyaluronate synthase 1; Hyaluronic acid synthase 1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Pig, Cow, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Hyaluronan synthase 1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 65 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Cardiovascular > Heart > Cardiogenesis > Stem cells Developmental Biology > Embryogenesis > Axis formation and symmetry Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Neurology process > Neurogenesis Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes |
| 亚细胞定位 | Membrane; Multi-pass membrane protein |
| 组织特异性 | Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. |
| 相似性 | Belongs to the NodC/HAS family. |
| 功能 | Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (Hyaluronan or hyaluronic acid). The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by beta-1,3 and beta-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS1 mRNA shows predominant expression in bone marrow mesenchymal progenitor cells and synovial cells. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 49.962 }}] {Pascual, Gloria. et al. Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Nature. 2021 Nov;:1-6} {IF} {Mouse}
[IF={{ 3.6 }}] {Romana Šínová. et al. The hyaluronan metabolism in the UV-irradiated human epidermis and the relevance of in vitro epidermal models. EXP DERMATOL. 2023 Jul;:} {IF} {Human}
[IF={{ 2.22 }}] {Yang, Guofeng, et al. "Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars." Journal of Molecular Histology: 1-8.} {IHC} {="Mouse"}
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HAS1 Rabbit pAb(bs-2946R)-50ul/200ul/100ul
￥1180 - 2800
