Sample:
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Lane 1: Human Jurkat cell lysates
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Lane 2: Human HepG2 cell lysates
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Lane 3: Human HeLa cell lysates
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Lane 4: Human HL-60 cell lysates
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Lane 5: Human SH-SY5Y cell lysates
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Primary: Anti-Nicastrin (bs-6058R) at 1/1000 dilution
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Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
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Predicted band size: 75 kDa
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Observed band size: 110 kDa
- ￥1180 - 2800
- Bioss
- bs-6058R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6058R |
| 英文名称 | Nicastrin Rabbit pAb |
| 中文名称 | 老年性痴呆蛋白APH2抗体 |
| 英文别名 | Anterior pharynx defective 2; APH 2; APH2; ATAG1874; KIAA0253; Ncstn; NCT; NICA_HUMAN; Nicastrin; RP11 517F10.1; RP11517F101. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Nicastrin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 75 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Proteases Stem Cells > Signaling Pathways > Notch > Cytoplasmic |
| 亚基 | Belongs to the nicastrin family. |
| 亚细胞定位 | Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| 组织特异性 | Widely expressed. |
| 相似性 | Belongs to the nicastrin family. |
| 功能 | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the ∫-Amyloid precursor protein (∫APP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of ∫APP and results in the overproduction of the neurotoxic ∫-Amyloid peptide, which results in a condition associated with Familial Alzheimer’s disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of ∫APP, which makes nicastrin an attractive potential target for modulating the production of ∫-Amyloid in patients with Alzheimer’s disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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[IF=8.58] Ku, Tingting, et al. "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM 2.5 aspiration." Particle and Fibre Toxicology 14.1 (2017): 34. WB ="Mouse"
[IF=1.396] Xiao YJ et al. hsa-miR-155 targeted NCSTN 3'UTR mutation promotes the pathogenesis and development of acne inversa. Int J Clin Exp Pathol. 2018;11(4):1878-1889. IHC Human
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NCSTN | Nicastrin Rabbit pAb(bs-6058R)-50ul/100ul/200ul
￥1180 - 2800
