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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-3619R |
| 英文名称 | Talin Rabbit pAb |
| 中文名称 | 踝蛋白抗体 |
| 英文别名 | TLN 1; ILWEQ; Talin 1; TLN; TLN1; TLN1_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Talin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 280 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Talin / Moesin |
| 亚基 | Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. |
| 亚细胞定位 | Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles. |
| 相似性 | Contains 1 FERM domain. Contains 1 I/LWEQ domain. |
| 功能 | Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 5.546 }}] {Yifan Wang. et al. Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force. J Cell Physiol. 2021 Mar;236(3):2156-2168} {WB} {Human}
[IF={{ 5.14 }}] {Dingyu, Wang, et al. "Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration." Molecular Neurobiology (2015): 1-14.} {WB} {="Rat"}
[IF={{ 3.42 }}] {He, Jing, et al. "The essential role of inorganic substrate in the migration and osteoblastic differentiation of mesenchymal stem cells." Journal of the Mechanical Behavior of Biomedical Materials (2016).} {Other} {="Rabbit"}
[IF={{ 3.235 }}] {Xian Tang. et al. Expression of Talin-1 in endometriosis and its possible role in pathogenesis. Reprod Biol Endocrin. 2021 Dec;19(1):1-10} {IHC} {Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
ITGA4（CD49D）信号通路、病理作用与靶向治疗药物研究梳理
等接头蛋白结合位点，其磷酸化修饰（如Ser1027）可调控信号转导。ITGA4主要与β1或β7亚基形成异二聚体（分别为VLA-4和α4β7），通过特异性识别配体中的Q-I-D-S或L-D-T序列，介导细胞与基质或内皮的黏附。 ITGA4的信号通路和调控 ITGA4本身虽不具备酶活性，但通过与β1或β7亚基形成异二聚体，构建了连接细胞外环境与细胞内骨架的独特双向信号转导机制。在“由内而外”的传导过程中，趋化因子或抗原刺激激活Rap1并招募Talin等接头蛋白，促使整合素胞外域从低亲和力弯曲构象
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
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