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Talin Rabbit pAb(bs-3619R)-50u

l/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-3619R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-3619R
    英文名称Talin Rabbit pAb
    中文名称踝蛋白抗体
    英文别名TLN 1; ILWEQ; Talin 1; TLN; TLN1; TLN1_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat (Human, Dog, Pig, Cow, Horse, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Talin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量280 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Talin / Moesin

    亚基Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.
    亚细胞定位Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles.
    相似性Contains 1 FERM domain.
    Contains 1 I/LWEQ domain.
    功能Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Talin) Polyclonal Antibody, Unconjugated (bs-3619R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Talin) Polyclonal Antibody, Unconjugated (bs-3619R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    该产品被引用文献

    [IF={{ 5.546 }}] {Yifan Wang. et al. Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force. J Cell Physiol. 2021 Mar;236(3):2156-2168} {WB} {Human}

    [IF={{ 5.14 }}] {Dingyu, Wang, et al. "Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration." Molecular Neurobiology (2015): 1-14.} {WB} {="Rat"}

    [IF={{ 3.42 }}] {He, Jing, et al. "The essential role of inorganic substrate in the migration and osteoblastic differentiation of mesenchymal stem cells." Journal of the Mechanical Behavior of Biomedical Materials (2016).} {Other} {="Rabbit"}

    [IF={{ 3.235 }}] {Xian Tang. et al. Expression of Talin-1 in endometriosis and its possible role in pathogenesis. Reprod Biol Endocrin. 2021 Dec;19(1):1-10} {IHC} {Human}

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    文献支持
    Talin Rabbit pAb(bs-3619R)-50ul/100ul/200ul
    ￥1180 - 2800