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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1659R |
| 英文名称 | phospho-STAT5a (Tyr694) Rabbit pAb |
| 中文名称 | 磷酸化信号转导和转录激活因子5a抗体 |
| 英文别名 | STAT5(phospho Y694); p-STAT5(phospho Y694); STAT5A(phospho-Tyr694); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5A; STA5A_RAT; STAT 5; STAT 5A; STAT5; STAT5A. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human STAT5a around the phosphorylation site of Tyr694 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 91 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Signaling Pathway > Nuclear Signaling > STATs |
| 亚基 | Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation. |
| 组织特异性 | Expressed in heart, lung, and weakly in muscle. |
| 翻译后修饰 | Tyrosine phosphorylated in response to IL2, IL3, IL7, IL15, KITLG/SCF, CSF2/GMCSF, GH1, PRL, EPO and THPO. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). |
| 相似性 | Belongs to the transcription factor STAT family. Contains 1 SH2 domain. |
| 功能 | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF=5] Ling Zuo. et al. Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. EUR J PHARMACOL. 2023 Jun;:175825 WB Rat
[IF=4.7] Shuo Wang. et al. Structure Optimization, Synthesis and Bioactivity Evaluation of Novel BCR-ABL Tyrosine Kinase Inhibitor Targeting T315I Mutation. CHEM-BIOL INTERACT. 2024 Sep;:111248 WB Human
[IF=2.1] Wenyan Yan. et al. Betaine Promotes Milk Protein Synthesis via Alleviating Oxidative Stress Caused by NEFA in Mammary Epithelial Cells of Dairy Cows. VET MED SCI. 2026 Jun;12(4):e71065 WB dairy cow
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Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse
. Deng, G.G., Martin‐McNulty, B., Sukovich, D.A., Freay, A., Halks‐Miller, M., Thinnes, T., Loskutoff, D.J., Carmeliet, P., Dole, W.P., and Wang, Y.X. 2003. Urokinase‐type plasminogen activator plays a critical
Generation of Spatio‐Temporally Controlled Targeted Somatic Mutations in the Mouse
. Calleja, C., Messaddeq, N., Chapellier, B., Yang, H., Krezel, W., Li, M., Metzger, D., Mascrez, B., Ohta, K., Kagechika, H., Endo, Y., Mark, M., Ghyselinck, N.B., and Chambon, P. 2006. Genetic
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