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- bs-4112R
- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4112R |
| 英文名称 | GABA A Receptor gamma 2 Rabbit pAb |
| 中文名称 | γ氨基丁酸γ2受体/GABAA Rγ2抗体 |
| 英文别名 | GABRG2; CAE 2; CAE2; ECA 2; ECA2; GABA(A) receptor subunit gamma 2; GABA(A) receptor subunit gamma-2; GABRG 2; GABRG2 antibody gamma aminobutyric acid(GABA) A receptor gamma 2; gamma aminobutyric acid A receptor gamma 2; gamma aminobutyric acid receptor gamma 2 subunit; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric-acid receptor gamma-2 subunit; GBRG2_HUMAN; GEFSP 3; GEFSP3. |
| 中文别名 | GABA A Receptor γ2; GABA A Receptor γ 2; GABA A Receptor γ-2; GABA A Receptor-γ2; |
| 产品应用 | WB=1:500-2000, IHC-P=1:200-800, IHC-F=1:200-800, IF=1:200-800 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GABRG2/GABA A Receptor gamma 2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 51 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Ligand-Gated Ion Channels > GABA Receptors Neuroscience > Neurotransmitter > Amino Acids > GABA |
| 亚基 | Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. |
| 亚细胞定位 | Cell membrane.; Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| 翻译后修饰 | Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability. |
| 相似性 | Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. |
| 功能 | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:200-800} |
| {IHC-F} | {1:200-800} |
| {IF} | {1:200-800} |
Cerebrum(Mouse) Lysate at 40 ug
Cerebrum(Rat) Lysate at 40 ug
Primary: Anti-GABA A Receptor gamma 2 (bs-4112R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
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文献和实验[IF={{ 6.8 }}] {Li Mingxing. et al. Caspase-1 affects chronic restraint stress-induced depression-like behaviors by modifying GABAergic dysfunction in the hippocampus. TRANSL PSYCHIAT. 2023 Jun;13(1):1-11} {WB} {Mouse}
[IF={{ 5.33 }}] {Jie-Dan Mu. et al. Acupuncture alleviates spinal hyperreflexia and motor dysfunction in post-ischemic stroke rats with spastic hypertonia via KCC2-mediated spinal GABAA activation. Exp Neurol. 2022 Mar;:114027} {IF} {Rat}
[IF={{ 1.703 }}] {Sun Tian-Yi. et al. Acupuncture improves the structure of spastic muscle and decreases spasticity by enhancing GABA, KCC2, and GABAAγ2 in the brainstem in rats after ischemic stroke. NEUROREPORT. 2022 Jun;33(9):399-407} {IF} {Rat}
[IF={{ 1.445 }}] {Deng CX et al. Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats. Chin J Integr Med. 2019 May 15.} {WB} {Rat}
Measurement of Chloride Movement in Neuronal Preparations
Majewska, M.D., Harrison, N.L., Schwartz, R.D., Barker, J.L., and Paul, S.M. 1986. Steroid hormone metabolites are barbiturate‐like modulators of the GABA receptor. Science 232:1004‐1007
secondary antibody review -- data from 99 publications
data
Characterization of Wild‐Type Excitatory Amino Acid Ion Channel Receptors
. Influences of ions, enzymes and detergents on gamma‐aminobutyric acid‐receptor binding in synaptic membranes of rat brain. Mol. Pharmacol. 13:442‐453. Ferkany, J.W., and Coyle, J.T
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