- ￥1180 - 2800
- Bioss
- bs-1838R
- 2025年10月24日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1838R |
| 英文名称 | KLF10 Rabbit pAb |
| 中文名称 | TGF-β诱导早期应答基因1抗体 |
| 英文别名 | TIEG1; TGF-beta inducible early growth response gene 1; Transforming growth factor-beta-inducible early growth response protein 1; Krueppel-like factor 10; TIEG-1; EGR-alpha; KLF10; TIEG; GDNF-inducible factor; Transcription factor GIF; mGIF; KLF10_HUMAN. |
| 产品应用 | ICC/IF=1:50-200 Not yet tested in other applications. |
| 交叉反应 | Human, Hela (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TIEG1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 53 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Growth factors > TGF Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Estrogen Cardiovascular > Heart > Hypertrophy > Transcription factors Epigenetics and Nuclear Signaling > Transcription > Domain Families > Krueppel like factor Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable). |
| 相似性 | Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. |
| 功能 | Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (KLF10) polyclonal Antibody, Unconjugated (bs-1838R) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
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KLF10 Rabbit pAb(bs-1838R)-50ul/100ul/200ul
￥1180 - 2800
