Sample:
_x000D_
Large intestine (Mouse) Lysate at 40 ug
_x000D_
Primary: Anti-CK20 (bs-1588R) at 1/300 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 48 kD
_x000D_
Observed band size: 48 kD
- ￥1180 - 2800
- Bioss
- bs-1588R
- 2026年10月13日
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- 文献和实验
- 技术资料
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1588R |
| 英文名称 | CK20 Rabbit pAb |
| 中文名称 | 细胞角蛋白20抗体 |
| 英文别名 | Cytokeratin 20; CK 20; CK20; Cytokeratin20; K20; Keratin 20; Keratin type I cytoskeletal 20; Keratin20; KRT 20; KRT 21; KRT20; KRT21; MGC35423; Protein IT; K1C20_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CK20 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 48 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins |
| 亚基 | Heterotetramer of two type I and two type II keratins. Associates with KRT8. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. |
| 翻译后修饰 | Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228._x000D_ |
| 相似性 | Belongs to the intermediate filament family. |
| 功能 | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cytokeratin 20 is a type I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system and is present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack cytokeratin 20. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF=7.419] Amira Abugomaa. et al. Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues. BIOMED PHARMACOTHER. 2022 Oct;154:113597 IHC Mouse
[IF=5.923] Mohamed Elbadawy. et al. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Jan;22(19):10763 IHC Bat
[IF=4.136] Yasushi Nakai. et al. 5‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis. ONCOL REP. 2022 Oct;48(4):1-13 IHC Mouse
[IF=3.998] Amira Abugomaa et al. Establishment of 2.5 D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports | (2020) 10:9393. ICC Dog
[IF=3.998] Abugomaa A et al. Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Sci Rep. 2020 Jun 10;10(1):9393. ICC Dog
相关实验
) ELISA 48T/96T 1500/2500 进口分装 F0148 可溶性白介素-18 受体 (sIL-18R) ELISA 48T/96T 1500/2500 进口分装 F0149 白介素-19(IL-19) ELISA 48T/96T 1500/2500 进口分装 F0150 白介素-20(IL-20) ELISA 48T/96T 1500/2500 进口分装 F0151 白介素-21(IL-21) ELISA 48T/96
) ELISA 48T/96T 1500/2500 进口分装 F0148 可溶性白介素-18 受体 (sIL-18R) ELISA 48T/96T 1500/2500 进口分装 F0149 白介素-19(IL-19) ELISA 48T/96T 1500/2500 进口分装 F0150 白介素-20(IL-20) ELISA 48T/96T 1500/2500 进口分装 F0151 白介素-21(IL-21) ELISA 48T/96
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KRT20 | CK-20 Rabbit pAb(bs-1588R)-50ul/100ul/200ul
￥1180 - 2800
