Blank control:RAW264.7.
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Primary Antibody (green line): Rabbit Anti-IL12RB1 antibody (bs-2603R)
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Dilution: 1ug/Test;
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Secondary Antibody (white blue line) : Goat anti-rabbit IgG-AF488
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Dilution: 0.5ug/Test.
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Isotype control（orange line）：Normal Rabbit IgG
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Protocol
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The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
- ￥1180 - 2800
- Bioss
- bs-2603R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2603R |
| 英文名称 | IL12RB1 Rabbit pAb |
| 中文名称 | 白细胞介素-12受体β1抗体 |
| 英文别名 | Interleukin-12 receptor subunit beta-1; IL12RB1; IL-12RB1; CD212; IL-12R-BETA1; IL12RB; MGC34454; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12RB1; IL-12R-beta-1; IL-12R subunit beta-1; IL-12 receptor subunit beta-1; I12R1_MOUSE. |
| 产品应用 | Flow-Cyt=1ug/Test Not yet tested in other applications. |
| 交叉反应 | Mouse (Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse IL-12RB1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 80 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚基 | Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 2 subfamily._x000D_
Contains 5 fibronectin type-III domains. |
| 功能 | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
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文献和实验该产品被引用文献
[IF=4.433] Jose Rosas Almanza. et al. IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury. J NEUROSCI RES. 2022 Sep;: IF Mouse
[IF=3.37] Terayama, Hayato, et al. "Contribution of IL-12/IL-35 Common Subunit p35 to Maintaining the Testicular Immune Privilege." PLoS ONE 9.4 (2014): e96120. IHC ="Mouse"
[IF=0] Li R et al. Osteogenic Effects of IL-12 on Bone Marrow Mesenchymal Stem Cells Facilitates Its Irradiation Hematopoiesis Recovery. 14 January 2020, PREPRINT (Version 1) available at Research Square WB Mouse
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Il12rb1 | CD212 Rabbit pAb(bs-2603R)-50ul/100ul/200ul
￥1180 - 2800
