Sample:
_x000D_
Liver (Mouse) Lysate at 40 ug
_x000D_
Ovary (Mouse) Lysate at 40 ug
_x000D_
Primary: Anti-TLR5 (bs-1197R) at 1/1000 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 95 kD
_x000D_
Observed band size: 130 kD
- ￥1180 - 2800
- Bioss
- bs-1197R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1197R |
| 英文名称 | TLR5 Rabbit pAb |
| 中文名称 | Toll样受体5抗体 |
| 英文别名 | toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3; CD285; TLR5_MOUSE. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse TLR5 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 95 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling |
| 亚基 | Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity). |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (By similarity). |
| 组织特异性 | Highly expressed in liver. Detected in lung and at very low levels in most other tissues. |
| 翻译后修饰 | Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity). |
| 相似性 | Belongs to the Toll-like receptor family. Contains 16 LRR (leucine-rich) repeats. Contains 1 TIR domain. |
| 功能 | Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
_x000D_ Raw264.7(Mouse) Cell Lysate at 30 ug
_x000D_ Hela(Human) Cell Lysate at 30 ug
_x000D_ Primary: Anti-TLR5 (bs-1197R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 95 kD
_x000D_ Observed band size: 130 kD
_x000D_ Raw264.7(Mouse) Cell Lysate at 30 ug
_x000D_ Hela(Human) Cell Lysate at 30 ug
_x000D_ Primary: Anti-TLR5 (bs-1197R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 95 kD
_x000D_ Observed band size: 130 kD
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文献和实验该产品被引用文献
[IF=5.959] Shi D et al. TLR5: A prognostic and monitoring indicator for triple-negative breast cancer. Cell Death Dis. 2019 Dec 18;10(12):954. IHC Mouse
[IF=4.26] Li, Chengcheng, et al. "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." Scientific Reports 7 (2017). WB ="Mouse"
[IF=3.829] Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11 WB Pig
[IF=3.7] Sun, Hukui, et al. "Non‐invasive imaging of allogeneic transplanted skin graft by 131I‐anti‐TLR5 mAb." Journal of Cellular and Molecular Medicine (2014). IHC ="Mouse"
[IF=3.42] Hao Jing. et al. rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner. CELL MOL IMMUNOL. 2013 Oct;11(2):206-214 WB ="Mouse"
相关实验
4, TLR5, TLR6 细胞膜 细菌细胞壁成分（LPS、肽聚糖、脂磷壁酸）、鞭毛蛋白 TLR1/2、TLR2/6：异源二聚；TLR4、TLR5：同源二聚 MyD88；TLR4还可通过TRIF通路传递信号 内体TLR TLR3, TLR7, TLR8, TLR9 内体/内溶酶体 核酸（dsRNA、ssRNA、CpG DNA） 同源二聚 TLR3: TRIF；TLR7/8/9: MyD88 孤儿TLR TLR10 主要为细胞膜，也有胞内
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
with studies on the pathogenesis of fever. The studies were performed by Menkin and Beeson in 1943-1948 on the fever producing properties of proteins released from rabbit peritoneal exudate Cell s. These studies were followed by contributions
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Tlr5 Rabbit pAb(bs-1197R)-50ul/100ul/200ul
￥1180 - 2800
