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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8524R |
| 英文名称 | Calcium Sensing Receptor Rabbit pAb |
| 中文名称 | 钙敏感受体1抗体 |
| 英文别名 | Ca sensing receptor; Ca2+sensing receptor 1; Ca2+sensing receptor; CAR; CaSR; CASR_HUMAN; EIG8; Extracellular calcium sensing receptor; Extracellular calcium sensing receptor [Precursor]; Extracellular calcium-sensing receptor [Precursor]; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; Hypocalciuric hypercalcemia 1; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism; MGC138441; NSHPT; Parathyroid Ca(2+) sensing receptor 1; Parathyroid Cell calcium sensing receptor; Parathyroid Cell calcium-sensing receptor; PCAR 1; PCAR1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Cow, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Calcium Sensing Receptor/CaSR |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 118 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Glutamate Receptors Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Metabolism > Vitamins / Minerals Signal Transduction > Signaling Pathway > Calcium Signaling Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR Signal Transduction > Signaling Pathway > Lipid Signaling > PLC |
| 亚基 | Interacts with VCP and RNF19A. Interacts with ARRB1 (By similarity). |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. |
| 翻译后修饰 | N-glycosylated. Ubiquitinated by RNF19A; which induces proteasomal degradation. |
| 相似性 | Belongs to the G-protein coupled receptor 3 family. |
| 功能 | Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Extracellular calcium-sensing receptor (CaSR), also designated parathyroid cell calcium-sensing receptor, is an integral membrane protein that belongs to the G protein-coupled receptor 3 family. CaSR is involved in maintaining a stable calcium concentration by acting as an sensor of the extracellular calcium levels for the parathyroid and kidney. Its activity is mediated by a G protein which activates a phosphatidylinositol-calcium second messenger |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验[IF={{ 5.279 }}] {Nan Gao. et al. Tryptophan Promotes Intestinal Immune Defense through Calcium-Sensing Receptor (CaSR)-Dependent Metabolic Pathways. J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX} {WB,FCM} {Pig}
[IF={{ 4.3 }}] {Shasha Chen. et al. Quercetin alleviates zearalenone-induced apoptosis and necroptosis of porcine renal epithelial cells by inhibiting CaSR/CaMKII signaling pathway. FOOD CHEM TOXICOL. 2023 Nov;:114184} {WB} {Pig}
[IF={{ 3.657 }}] {Liu H et al. Involvement of calcium-sensing receptor activation in the alleviation of intestinal inflammation in a piglet model by dietary aromatic amino acid supplementation. (2018) Br J Nutr.;120(12):1321-1331.} {WB} {piglet}
[IF={{ 2.91 }}] {Huang, Bo, et al. "Chitosan oligosaccharide reduces intestinal inflammation that involves CaSR activation in LPS challenged-piglets." Journal of Agricultural and Food Chemistry (2016).} {WB} {="Pig"}
[IF={{ 2.299 }}] {Zhang P et al. Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells. Int J Endocrinol. 2020 Jun 12;2020:1860842.} {WB} {Rat}
G Protein-Coupled Receptor Pharmacogenetics
are reviewed with respect to a limited sampling of GPCR systems, including the β2 -adrenergic receptors, the cysteinyl leukotriene receptors, and the calcium-sensing receptor. In each example, the nature of the disruption to receptor function that results
G Protein-Coupled Receptors Disrupted in Human Genetic Disease
of inactivating and activating calcium-sensing receptor (CASR) muta tions is discussed with respect to familial hypocalciuric hypercalemia (FHH) and autosomal dominant hypocalemia (ADH). Among ADH mutations, those associ ated with tonic–clonic seizures
MDR1 exon23/27/28 MDR1 exon1~5 MDR1 exon6/13/15/16/17 MDR1 exon19/21/24/25 P53 exon 5~9 H-ras Exon1/2 LPTS/PinX1 flt-1 KDR connexin32/NM_000166 connexin43/NM_000165 biotinidase/AH006174 HLCS/AB063285 Ⅰ型胶原 CASR（calcium sensing receptor
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