Podoplanin Rabbit pAb(bs-10673R)-50ul/100ul/200ul

Podoplanin Rabbit pAb(bs-10673

R)-50ul/100ul/200ul
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  • ¥1180 - 2800
  • Bioss已认证
  • bs-10673R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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    • 规格

      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-10673R
    英文名称Podoplanin Rabbit pAb
    中文名称平足蛋白/淋巴管内皮细胞蛋白抗体
    英文别名PDPN_HUMAN; DPN; GP36; Aggrus; Glycoprotein 36(Gp36); PA2.26 antigen; T1-alpha; T1A; 29kDa cytosolic podoplanin intracellular domain; PICD; PSEC0003; PSEC0025;
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Podoplanin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量15 kDa
    实际分子量36-40 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Endothelial Cell Markers

    Cardiovascular > Blood

    Cardiovascular > Vasculature > Endothelium

    Tags & Cell Markers > Cell Type Markers > Other Cell Types

    亚细胞定位Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
    组织特异性Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
    翻译后修饰Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. The N-terminus is blocked.
    相似性Belongs to the podoplanin family.
    功能May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    Podoplanin Rabbit pAb(bs-10673
    Sample:
    Lane 1: U2os (Human) Cell Lysate at 30 ug
    Lane 2: U87MG (Human) Cell Lysate at 30 ug
    Lane 3: 293T (Human) Cell Lysate at 30 ug
    Lane 4: MG63 (Human) Cell Lysate at 30 ug
    Lane 5: U251 (Human) Cell Lysate at 30 ug
    Primary:
    Anti-Podoplanin (bs-10673R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 35 kD
    Observed band size: 35 kD
    Podoplanin Rabbit pAb(bs-10673
    Sample:
    MG63(Human) Cell Lysate at 30 ug
    Primary: Anti- Podoplanin (bs-10673R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 15 kD
    Observed band size: 37kD

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