C5 | Complement C5a Rabbit pAb(bs-15197R)-50ul/100ul/200ul产品图
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C5 | Complement C5a Rabbit pAb

(bs-15197R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-15197R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-15197R
    英文名称C5a Rabbit pAb
    中文名称补体C5抗体
    英文别名Anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5; CO5_HUMAN; Complement C5 alpha'' chain; Complement C5; Complement component C5; CPAMD4.
    产品应用WB=1:500-2000, Flow-Cyt=2ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Complement C5 alpha chain
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量104/112 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Other Antibodies > Oxidative Stress

    Immunology > Innate Immunity > Complement > Alternative Pathway

    Immunology > Innate Immunity > Complement > Classical Pathway

    Immunology > Innate Immunity > Complement > MAC

    Immunology > Innate Immunity > Macrophage / Inflamm.

    Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

    Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR

    亚基C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Interacts with tick complement inhibitor.
    亚细胞定位Secreted.
    相似性Contains 1 anaphylatoxin-like domain._x000D_ Contains 1 NTR domain.
    功能Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled._x000D_ Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Activation of the complement system plays a key role in normal inflammatory response to injury but may cause substantial injury when activated inappropriately. The complement system is activated either through the classical (antibody induced) or the alternative (microbial surface, polysacharride induced) pathway, both leading to the formation of the C5b9 complex. Fluid phase binding of the multifunctional glycoprotein S protein (vitronectin) to C5b9 leads to the formation of a cytolytically inactive complex, SC5b9, which is unable to attach to cells.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {Flow-Cyt}{2ug/Test}

     

    产品细节图片1
    Blank control: HepG2.
    _x000D_ Primary Antibody (green line): Rabbit Anti-C5 antibody (bs-15197R)
    _x000D_ Dilution: 2μg /10^6 cells;
    _x000D_ Isotype Control Antibody (orange line): Rabbit IgG .
    _x000D_ Secondary Antibody : Goat anti-rabbit IgG-AF647
    _x000D_ Dilution: 1μg /test.
    _x000D_ Protocol
    _x000D_ The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed._x000D_
    产品细节图片2
    Sample:
    _x000D_ Lane 1: A549 (Human) Cell Lysate at 30 ug
    _x000D_ Lane 2: Hela (Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-C5a (bs-15197R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 115/105 kD
    _x000D_ Observed band size: 115 kD

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    图标文献和实验
    该产品被引用文献

    [IF=9.3] Hartmannsberger Beate. et al. Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome. J NEUROINFLAMM. 2024 Dec;21(1):1-15 IF Human

    [IF=6.2] Chuanxin Liu. et al. Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis. ECOTOX ENVIRON SAFE. 2025 Jan;289:117441 WB Rat

    [IF=5.23] Liu, Long, et al. "Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System."Scientific Reports 6 (2016): 31763. WB ="Others"

    [IF=5.1] Wen Liao. et al. Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. FOOD FUNCT. 2024 Dec;: WB Mouse

    [IF=5.1] Wen Liao. et al.Lactobacillus rhamnosusLC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway†.FOOD & FUNCTION.2025 Jan 20;16(2):475-486. Western blot Mouse

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    C5 | Complement C5a Rabbit pAb(bs-15197R)-50ul/100ul/200ul
    ￥1180 - 2800