TSHR | LGR3 (CT) Rabbit pAb(bs-0206R)-50ul/100ul/200ul产品图
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TSHR | LGR3 (CT) Rabbit pAb(bs

-0206R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-0206R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0206R
    英文名称TSHR (CT) Rabbit pAb
    中文名称促甲状腺素受体抗体（C端）
    英文别名hTSHR I; hTSHRI; LGR 3; LGR3; MGC75129; Thyroid adenoma hyperfunctioning; Thyroid carcinoma with thyrotoxicosis; Thyroid Stimulating Hormone Receptor; Thyrotropin Receptor; Thyrotropin receptor I; TSH R; TSHR; Thyroid stimulating hormone receptor; TSHR_HUMAN.
    中文别名促甲状腺激素受体
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Rat, Chicken, Pig, Cow, Horse, Rabbit, GuineaPig)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TSHR
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量86 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Endocrine system > Thyroid axis

    Signal Transduction > Growth Factors/Hormones > Hormones

    亚基Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Expressed in the thyroid.
    相似性Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily._x000D_
    Contains 7 LRR (leucine-rich) repeats.
    功能Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Tissue/cell: human thyroid carcinoma; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    _x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    _x000D_ Incubation: Anti-TSHR(CT) Polyclonal Antibody, Unconjugated(bs-0206R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    _x000D_
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded (human parotid gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TSHR) Polyclonal Antibody, Unconjugated (bs-0206R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. _x000D_
    产品细节图片3
    Sample:
    _x000D_ Lane 1: Human Jurkat cell lysates
    _x000D_ Lane 2: Human TT cell lysates
    _x000D_ Primary: Anti-TSHR (CT) (bs-0206R) at 1/2000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 86 kD
    _x000D_ Observed band size: 130 kD

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    图标文献和实验
    该产品被引用文献

    [IF=4.3] Cheng Junshuai. et al. Effects of Iodine Nutritional Status on Thyroid Proliferation of SD Rat. BIOL TRACE ELEM RES. 2026 May;:1-10 WB Rat

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    TSHR | LGR3 (CT) Rabbit pAb(bs-0206R)-50ul/100ul/200ul
    ￥1180 - 2800