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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6219R |
| 英文名称 | RXR beta Rabbit pAb |
| 中文名称 | 核受体RXRβ抗体 |
| 英文别名 | Retinoid X Receptor beta; DAUD I6; DAUDI6; H 2RIIBP; H2RIIBP; MHC class I promoter binding protein; NR2B2; RCoR 1; RCoR1; Retinoic acid receptor RXR beta; RXR beta; RXRB; RXRbeta. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Pig, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RXR beta |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 59 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Retanoic and retanoid Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Retinoic & Retinoid Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Retinoic & Retinoid |
| 亚基 | Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in a variety of tumor cell lines. |
| 相似性 | Belongs to the nuclear hormone receptor family. NR2 subfamily._x000D_
Contains 1 nuclear receptor DNA-binding domain._x000D_ |
| 功能 | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
_x000D_ Spleen (Mouse) Lysate at 40 ug
_x000D_ Heart (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti-RXR beta (bs-6219R) at 1/300 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 59 kD
_x000D_ Observed band size: 65 kD
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文献和实验[IF=9.8] Yanghuan Yu. et al. MiRNA-seq and mRNA-seq revealed the mechanism of fluoride-induced cauda epididymal injury. SCI TOTAL ENVIRON. 2024 Jun;930:172895 WB Mouse
[IF=5.6] Ling-Hua Chang. et al. Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression. INT J MOL SCI. 2023 Jan;24(17):13414 IHC Rat
Expanding Mouse Ventricular Cardiomyocytes Through GSK‐3 Inhibition
) Connexin‐43 (Cx43, rabbit polyclonal, Sigma, cat. no. C6219, 1 mg/ml, 1:150) Secondary antibodies
Generation of Spatio‐Temporally Controlled Targeted Somatic Mutations in the Mouse
of CreERT2. J. Immunol. 182:5633‐5640. Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., and Birchmeier, W. 2001. Beta‐Catenin controls hair follicle morphogenesis and stem
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