Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-CCR1 Polyclonal Antibody, Unconjugated(bs-1169R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
- ￥1180 - 2800
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- bs-1169R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1169R |
| 英文名称 | CCR-1/CD191 Rabbit pAb |
| 中文名称 | 细胞表面趋化因子受体1抗体 |
| 英文别名 | CC chemokine receptor 1; A630091E18Rik; CC-CKR-11; CCBP2; CCR10; CCR11; CCRL1; CCX-CKR; CCX-CKR1; CKR-11; Cmkbrl1; LOC684092; LOC685243; PPR1; VSHK1; C C chemokine receptor type 1; C C CKR 1; CC CKR 1; CCR 1; CD 191; CD191; CD191; Chemokine(C-C motif) receptor 1; Chemokine C C motif receptor 1; CKR 1; CKR1; CMKBR 1; CMKBR1; CMKR 1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1 alpha/Rantes receptor; Macrophage inflammatory protein 1 alpha receptor; MIP 1alpha R; Mip-1a-R; MIP1aR; RANTES R; RANTES receptor; SCYAR1; CCR1_HUMAN; C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; Short=CCR-1; CCR1; LD78 receptor; MIP-1alpha-R; RANTES-R; CD191. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CCR-1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 40 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Chemokines > Beta Chemokine Rec. (CCR) Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus |
| 亚基 | Interacts with CREB3. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Widely expressed in different hematopoietic cells. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-1169P is a synthetic peptide derived from human CCR-1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验该产品被引用文献
[IF={{ 5.4 }}] {Wangxia Peng. et al. Network pharmacology combines machine learning, molecular simulation dynamics and experimental validation to explore the mechanism of acetylbinankadsurin a in the treatment of liver fibrosis. J ETHNOPHARMACOL. 2023 Dec;:117682} {WB,IF} {Human}
[IF={{ 3.8 }}] {Wu Zhenyu. et al. Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor. NEUROCHEM RES. 2025 Aug;50(4):1-22} {WB} {Mouse}
[IF={{ 3 }}] {Ming Chen. et al. Oxymatrine alleviates NSAID-associated small bowel mucosal injury by regulating MIP-1/CCR1 signalling and gut microbiota. J PHARMACOL SCI. 2024 Nov;156:149} {IHC} {Rat}
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CCR-1/CD191 Rabbit pAb(bs-1169R)-50ul/100ul/200ul
￥1180 - 2800
