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产品信息以Bioss网站为准
- 规格:
50ul/100ul
| 规格: | 50ul | 产品价格: | ¥1180.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥1980.0 |
| 产品编号 | bs-6703R |
| 英文名称 | RAB7A Rabbit pAb |
| 中文名称 | RAS癌基因相关蛋白RAB7抗体 |
| 英文别名 | RAB7A_HUMAN; Ras-related protein Rab-7a; EC:3.6.5.2; RAB7; |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RAB7A |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 23 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family Tags & Cell Markers > Subcellular Markers > Organelles > Endosome Tags & Cell Markers > Subcellular Markers > Organelles > Lysosome |
| 亚基 | Interacts with RILP. Interacts with PSMA7. Interacts with RNF115. Interacts with FYCO1 |
| 亚细胞定位 | Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| 组织特异性 | Widely expressed; high expression found in skeletal muscle. |
| 相似性 | Belongs to the small GTPase superfamily. Rab family. |
| 功能 | Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the RAB family of RAS related GTP binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |

Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Lung tissue lysates
Lane 3: Human HeLa cell lysates
Lane 4: Human A431 cell lysates
Lane 5: Human HL-60 cell lysates
Primary: Anti-RAB7 (bs-6703R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kDa
Observed band size: 21 kDa
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文献和实验[IF={{ 8 }}] {Dixit, Saurabh, et al. "Caveolin-mediated endocytosis of the Chlamydia M278 outer membrane peptide encapsulated in poly (lactic acid)-Poly (ethylene glycol) nanoparticles by mouse primary dendritic cells enhances specific immune effectors mediated by MHC class II and CD4+ T cells." Biomaterials (2017).} {ICC} {="Mouse"}
[IF={{ 7.546 }}] {Luo R et al. Clostridium perfringens beta2 toxin induced in vitro oxidative damage and its toxic assessment in porcine small intestinal epithelial cell lines. Gene. 2020 Oct 30;759:144999.} {WB} {Rat}
[IF={{ 7.546 }}] {Zixuan Liu. et al. Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation. Part Fibre Toxicol. 2020 Dec;17(1):1-17} {WB} {Rat}
[IF={{ 6.656 }}] {Ye Yang. et al. Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway. PHYTOMEDICINE. 2023 Feb;110:154625} {WB} {Rat}
[IF={{ 4.7 }}] {Joshua Williams. et al. Genetic Engineering of Bacteriophage K1F with Human Epidermal Growth Factor to Enhance Killing of Intracellular E. coli K1. ACS SYNTH BIOL. 2023;XXXX(XXX):XXX-XXX} {IF} {Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
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