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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1097R |
| 英文名称 | PAX3 Rabbit pAb |
| 中文名称 | 配对盒基因3抗体 |
| 英文别名 | CDHS; HUP 2; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box homeotic gene 3; Paired box protein Pax 3; Paired box protein Pax3; paired domain gene 3; paired domain gene HuP2; PAX 3; PAX3/FKHR fusion gene; Waardenburg syndrome 1; WS 1; WS1. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PAX3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 53 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Lineage specification > Ectoderm Developmental Biology > Organogenesis > Nervous system development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > PAX Stem Cells > Lineage Markers > Ectoderm Stem Cells > Mesenchymal Stem Cells > Myogenesis Stem Cells > Neural Stem Cells > Intracellular Stem Cells > Neural Stem Cells > Neural Crest Stem Cells |
| 亚基 | Can bind to DNA as a homodimer or a heterodimer with PAX7. Interacts with PAXBP1; the interaction links PAX3 to a WDR5-containing histone methyltransferase complex. Interacts with DAXX. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the paired homeobox family._x000D_
Contains 1 homeobox DNA-binding domain._x000D_ Contains 1 paired domain. |
| 功能 | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This protein is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These proteins play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-PAX3 Polyclonal Antibody, Unconjugated(bs-1097R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-PAX3 Polyclonal Antibody, Unconjugated(bs-1097R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
_x000D_ Brain (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti-PAX3 (bs-1097R) at 1/300 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 53 kD
_x000D_ Observed band size: 53 kD
_x000D_ Lane 1: Mouse Cerebellum tissue lysates
_x000D_ Lane 2: Mouse Muscle tissue lysates
_x000D_ Lane 3: Rat Cerebellum tissue lysates
_x000D_ Lane 4: Rat Muscle tissue lysates
_x000D_ Primary: Anti-PAX3 (bs-1097R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 53 kDa
_x000D_ Observed band size: 53 kDa
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文献和实验[IF=4.925] Yuanyuan Chen. et al. Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV). INVEST OPHTH VIS SCI. 2023 Mar;64(3):8-8 IHC Human
[IF=4.5] Dong Changsheng. et al. Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure. SCI REP-UK. 2017 Oct;7(1):1-12 WB ="Mouse"
[IF=4.4] Li Zhang. et al. Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation. NEUROCHEM INT. 2024 Sep;:105861 IHC Mouse
[IF=3.8] Xu, Dan, et al. "High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats." Toxicology Letters (2017). IF =""
[IF=3.04] Bonchak, Jonathan G., et al. "Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin." Archives of Biochemistry and Biophysics (2014). IHC ="Human"
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