Sample:
_x000D_
HepG2(Human) Cell Lysate at 30 ug
_x000D_
Primary: Anti-CD137 (bs-2449R) at 1/500 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 25 kD
_x000D_
Observed band size: 39 kD
- ￥1180 - 2800
- Bioss
- bs-2449R
- 2026年10月13日
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- 技术资料
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2449R |
| 英文名称 | CD137 Rabbit pAb |
| 中文名称 | 肿瘤坏死因子受体超家族成员9抗体 |
| 英文别名 | Tumor necrosis factor receptor superfamily member 9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activation; ILA; Interleukin activated receptor homolog of mouse Ly63; Ly63; MGC2172; MGC114552; OTTHUMP00000044294; TNR9_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD137 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 25 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Expressed on the surface of activated T-cells. |
| 相似性 | Contains 4 TNFR-Cys repeats. |
| 功能 | Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
_x000D_ Lane 1: Mouse Thymus Lysates
_x000D_ Lane 2: Mouse Spleen Lysates
_x000D_ Lane 2: Mouse Lymph Lysates
_x000D_ _x000D_ _x000D_ Primary: Anti-CD137 (bs-2449R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 25kDa
_x000D_ Observed band size: 42kDa
_x000D_ Lane 1: Mouse Thymus Lysates
_x000D_ Lane 2: Mouse Spleen Lysates
_x000D_ Lane 2: Mouse Lymph Lysates
_x000D_ _x000D_ _x000D_ Primary: Anti-CD137 (bs-2449R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 25kDa
_x000D_ Observed band size: 42kDa
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文献和实验该产品被引用文献
[IF=8.38] Daquinag, A. C., et al. "Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development." Cell Death & Differentiation (2014). Other ="Mouse"
[IF=3.79] Claycombe, Kate J., et al. "Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (9Ga) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets." The Journal of Nutritional Biochemistry (2016). FCM ="Rat"
[IF=3.743] Lei W et al. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improvingatherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomed Pharmacother. 2019 Jun 6;117:109074. WB Mouse
[IF=3.7] Lilan Zhang. et al. KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state. CELL SIGNAL. 2025 Nov;:112214 WB Porcine
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TNFRSF9 | CD137/4-1BB Rabbit pAb(bs-2449R)-50ul/100ul/200ul
￥1180 - 2800
