Sample:
Lane 1: Human THP-1(LPS) cell lysates
Lane 2: Human THP-1 cell lysates
Lane 3: Human Jurkat cell lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human 293T cell lysates
Primary: Anti-TLR7 (bs-6601R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 121 kDa
Observed band size: 65,121 kDa
- ￥1180 - 1980
- Bioss
- bs-6601R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-6601R |
| 英文名称 | TLR7 Rabbit pAb |
| 中文名称 | Toll样受体7抗体 |
| 英文别名 | TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TLR7 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 121 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling Signal Transduction > Adapters > Transmembrane |
| 亚基 | Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. |
| 组织特异性 | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. |
| 相似性 | Belongs to the Toll-like receptor family. Contains 27 LRR (leucine-rich) repeats. Contains 1 TIR domain. |
| 功能 | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 8.386 }}] {Umehara T et al. Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm. PLoS Biol. 2019 Aug 13;17(8):e3000398.} {WB} {Mouse}
[IF={{ 8.025 }}] {Fei Wen. et al. TLR7/8 agonist (R848) inhibit bovine X sperm motility via PI3K/GSK3α/β and PI3K/NFκB pathways. INT J BIOL MACROMOL. 2023 Mar;232:123485} {IF} {Bovine}
[IF={{ 7.3 }}] {Kohtaro Fukuyama. et al. Establishment of a porcine bronchial epithelial cell line and its application to study innate immunity in the respiratory epithelium. FRONT IMMUNOL. 2023; 14: 1117102} {ICC} {Pig}
[IF={{ 4.1 }}] {Ruifeng Zhao. et al. Evidence Against the Role of Toll-Like Receptors 7 and 8 in Sex Selection in Mice, Cattle and Humans. ISCIENCE. 2025 Jul;:113164} {IF,WB} {Mouse,Bovine,Human}
[IF={{ 3.777 }}] {Ling Shuai. et al. Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice. AM J REPROD IMMUNOL. 2023 Feb;:} {WB} {Mouse}
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TLR7 Rabbit pAb(bs-6601R)-50ul/100ul
￥1180 - 1980
