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- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-3576R |
| 英文名称 | HBEGF Rabbit pAb |
| 中文名称 | 肝素结合性表皮生长因子抗体 |
| 英文别名 | HB EGF; Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF_HUMAN; HEGFL; heparin binding EGF like growth factor; Heparin binding epidermal growth factor; Heparin binding epidermal growth factor like growth factor; Heparin-binding EGF-like growth factor; Proheparin binding EGF like growth factor. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HB-EGF |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 21 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Growth factors > EGF Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Signal Transduction > Growth Factors/Hormones > EGF |
| 亚基 | Interacts with FBLN1. Interacts with EGFR and ERBB4. |
| 亚细胞定位 | Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor. Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein. |
| 翻译后修饰 | Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active. O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44. |
| 相似性 | Contains 1 EGF-like domain. |
| 功能 | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a 22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of 19-23 kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or Nterminal truncation. HB-EGF is synthesized as a membrane-anchored precursor(proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively.HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparan sulfate proteoglycan. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 4.61 }}] {Lebkuechner et al. Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency. (2015) J.Neurochem. 135:234-48} {ICC} {Mouse}
[IF={{ 4.28 }}] {Lebkuechner, Isabell, et al. "Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency." Journal of Neurochemistry(2015).} {Other} {="Mouse"}
[IF={{ 12.121 }}] {Maximilian Strunzet al. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in Human lung fibrosis. Nat Commun . 2020 Jul 16;11(1):3559.} {IF} {mouse}
[IF={{ 10.7 }}] {Xiangyi Ke. et al. Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. DEV CELL. 2024 Dec 11} {IF} {Mouse}
[IF={{ 10.7 }}] {Xiangyi Ke. et al.Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate..DEVELOPMENTAL CELL.2025 Mar 24;60(6):819-836.e7.} {IF} {Human,Mouse}
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