Sample:
Spinal cord (Mouse) Lysate at 40 ug
Spinal cord (Rat) Lysate at 40 ug
Primary:Anti-KiSS1 receptor (bs-2501R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kD
Observed band size: 59 kD
- ￥1180 - 2800
- Bioss
- bs-2501R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2501R |
| 英文名称 | KiSS1 receptor Rabbit pAb |
| 中文名称 | G蛋白偶联受体54抗体 |
| 英文别名 | AXOR 12; AXOR12; G protein coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; GPCR 54; GPCR54; GPR 54; GPR54; HOT7T175; Hypogonadotropin 1; Hypogonadotropin-1; Hypogonadotropin1; KISS 1 receptor; KISS 1R; KiSS-1 receptor; KiSS1R; KiSS-1R; KISS1 receptor; KISS1R; Kisspeptins receptor; KISSR_HUMAN; Metastin receptor; OT7T175. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Dog, Pig, Sheep, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GPR54 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 44 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neuroendocrinology > General neuroendocrinology Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Lane 1: Spinal cord (Mouse) Lysate at 40 ug
Lane 2: Pancreas (Mouse) Lysate at 40 ug
Lane 3: Placenta (Mouse) Lysate at 40 ug
Lane 4: Spinal cord (Rat) Lysate at 40 ug
Lane 5: Pancreas (Rat) Lysate at 40 ug
Lane 6: Thymus (Rat) Lysate at 40 ug
Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug
Lane 8: K562 (Human) Cell Lysate at 30 ug
Lane 9: HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti-KiSS1 receptor (bs-2501R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45-55/75/125 kD
Observed band size: 45-55/75/125 kD
Lane 1: Spinal cord (Mouse) Lysate at 40 ug
Lane 2: Pancreas (Mouse) Lysate at 40 ug
Lane 3: Placenta (Mouse) Lysate at 40 ug
Lane 4: Spinal cord (Rat) Lysate at 40 ug
Lane 5: Pancreas (Rat) Lysate at 40 ug
Lane 6: Thymus (Rat) Lysate at 40 ug
Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug
Lane 8: K562 (Human) Cell Lysate at 30 ug
Lane 9: HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti-KiSS1 receptor (bs-2501R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45-55/75/125 kD
Observed band size: 45-55/75/125 kD
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文献和实验该产品被引用文献
[IF={{ 6.17 }}] {Yi Huang. et al. Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway. Free Radical Bio Med. 2021 Aug;171:99} {WB,IF,IP} {Rat}
[IF={{ 5.2 }}] {Marianna Marino. et al. The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction in vivo. FRONT ENDOCRINOL. 2023; 14: 1269334} {IF,IHC} {Rat}
[IF={{ 4.872 }}] {Jin H et al. Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in miceEcotoxicol Environ Saf.2021 Jan 15;208:111748.} {IF} {Mouse}
[IF={{ 4.736 }}] {Lu Xiaosheng. et al. Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control. ENDOCRINOLOGY. 2022 Apr;:} {IHC} {Mouse}
[IF={{ 4.096 }}] {Elena Mele. et al. Differential Expression of Kisspeptin System and Kisspeptin Receptor Trafficking during Spermatozoa Transit in the Epididymis. Genes-Basel. 2022 Feb;13(2):295} {IF} {Rat}
相关实验
, Algermissen, B. et al. 3. Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine Sepharose 6B. J. Chromatogr. (1989), 475 363-72, Stell, J. G. P. et al. 4. The Crystal Structure of a T Cell Receptor in Complex
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/96T 2000/3000 进口分装 F0021 骨成型蛋白-9(BMP-9) ELISA 48T/96T 2000/3000 进口分装 F0022 BMP-R1A ELISA 48T/96T 2000/3000 进口分装 F0023 BMP-R2 ELISA 48T/96T 2000/3000 进口分装 F0024 BTC ELISA 48T/96T 2000/3100 进口分装 F0030 CAE-Ab ELISA 96
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KiSS1 receptor Rabbit pAb(bs-2501R)-50ul/100ul/200ul
￥1180 - 2800
