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- 2026年10月13日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 规格： | 200ug | 产品价格： | ￥5600.0 |
| 产品编号 | bsm-2024M |
| 英文名称 | HBsAg Mouse mAb |
| 中文名称 | 人乙型肝炎表面抗原单克隆抗体（检测） |
| 英文别名 | L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S; HBSAG_HBVC5. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (HBsAg) |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant HBsAg protein |
| 亚型 | IgM |
| 性状 | Liquid |
| 纯化方法 | affinity purified |
| 克隆类型 | Monoclonal |
| 理论分子量 | 44 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 研究领域 | Microbiology > Organism > Virus > DNA Virus > double stranded DNA Virus > Hepatitis B |
| 亚基 | Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. |
| 亚细胞定位 | Virion membrane. |
| 翻译后修饰 | Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region._x000D_
Myristoylated. |
| 相似性 | Belongs to the orthohepadnavirus major surface antigen family. |
| 功能 | The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein._x000D_
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF=11.15] Liu, Chang. et al. Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides. BMC MED. 2022 Dec;20(1):1-17 IHC Mouse
-mouse-mab.html 可用于乳腺癌组织的免疫组化分析 Ki67 Antidiv (YA322) (HY-P80506) www.medchemexpress.cn/antibody/ki67-rabbit-mab.html 可用于乳腺癌组织的免疫组化分析 p53 Antidiv (YA250) (HY-P80257) www.medchemexpress.cn/antibody/p53-rabbit-mab.html 可用于乳腺癌组织的免疫组化分析 Cytokeratin 7 Antidiv
mRNA. 王平et al针对HBV前-C／C区基因的锤头状核酶，经体外转录后可定点切割靶RNA，在HepG2细胞亦可显著抑制 HBeAg、HBsAg的表达和HBV DNA复制；Weizsacker et al构建了***的核酶，针对HBV mRNA第2029-2031 nt，2044-2046 nt和2049-2051 nt位点设计的3组锤头状核酶，可有效的切割靶RNA，抑制或阻断HBV的复制，并可减少变异病毒逃逸的机会. Beck et al设计了针对HBV包装点的锤头状核酶，体外切割靶RNA
IgG单克隆抗体 Phospho-Tau抗体(YA3436)(HY-P83700) www.medchemexpress.cn/antibody/phospho-tau-ser202-thr205-antibody.html 抗磷酸化Tau(Ser202/Thr205) 的IgG单克隆抗体 GFAP抗体(YA755)(HY-P80139) www.medchemexpress.cn/antibody/gfap-mouse-mab.html 抗 GFAP的IgG1单克隆抗体 参考
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