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- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1698R |
| 英文名称 | ox-LDL Rabbit pAb |
| 中文名称 | 氧化低密度脂蛋白抗体 |
| 英文别名 | ox-LDL: LDL(Copper oxidized); Cu2SO4 oxidized low density lipoprotein; oxidized low density lipoprotein; Low density lipoprotein; MDA oxidized LDL; MDA oxidized low density lipoprotein. |
| 中文别名 | 氧化型低密度脂蛋白； |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=2ug/Test Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | Full length protein from human plasma |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 31 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Secreted. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {2ug/Test} |
Primary Antibody (green line): Rabbit Anti-ox-LDL antibody (bs-1698R)
Dilution: 3μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody : Goat anti-rabbit IgG-AF647
Dilution: 3μg /test.
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
Primary Antibody (green line): Rabbit Anti-ox-LDL antibody (bs-1698R)
Dilution: 2ug/Test;
Secondary Antibody : Goat anti-rabbit IgG-FITC
Dilution: 0.5ug/Test.
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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文献和实验[IF={{ 7.396 }}] {Takuya Tsumita. et al. The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells. INT J CANCER. 2022 May 24} {IF} {Mouse}
[IF={{ 6.706 }}] {Qing Li. et al. Re-Visiting Antioxidant Therapy in Murine Advanced Atherosclerosis with Brussels Chicory, a Typical Vegetable in Mediterranean Diets. NUTRIENTS. 2023 Jan;15(4):832} {IHC} {Mouse}
[IF={{ 4.473 }}] {Xiaosu Song. et al. Long noncoding RNA THRIL promotes foam cell formation and inflammation in macrophages. CELL BIOL INT. 2022 Oct;:} {Other} {Other}
[IF={{ 4.39 }}] {Wen, Song, et al. "OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice." Journal of Lipid Research 53.5 (2012): 829-838.} {IHC} {="Mouse"}
[IF={{ 4.164 }}] {Fen Gao. et al. Angiotensin II induces the expression of periostin to promote foam cell formation in oxLDL-treated macrophages. Int J Cardiol. 2022 Jan;347:46} {ELISA} {Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
OLR1（LOX-1）配体结合机制、胞内信号调控及蛋白试剂应用解析
的信号通路和调控 当氧化低密度脂蛋白（Ox-LDL）与LOX-1受体结合后，会触发一系列复杂的细胞内信号级联反应，从根本上改变细胞的生理状态。首先，这种结合会导致细胞内活性氧（ROS）水平显著升高，同时抑制一氧化氮（NO）的正常释放。这种氧化应激环境不仅直接损伤细胞，还激活了PI3K/AKT/GSK3β这一关键信号通路。 随之而来的是转录层面的剧烈变化。上述信号通路共同作用，激活了NF-κB以及上皮-间充质转化（EMT）相关的转录因子。NO的减少进一步加剧了炎症反应，促使IL-6、IL-8和IL
- a ) ELISA 48T/96T 1300/2300 进口分装 F1697 大鼠可溶性肿瘤坏死因子- 受体 (rat TNF-R ) ELISA 48T/96T 2000/3000 进口分装 F1698 大鼠组织纤溶酶原激活剂(rat t-PA) ELISA 48T/96T 2000/3000 进口分装 F1699 大鼠血小板生成素(rat TPO) ELISA 48T/96T 2000/3000 进口分装 F1710 大鼠尿激酶型纤溶酶原(rat
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