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- bsm-1622M
- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 规格： | 200ug | 产品价格： | ￥5600.0 |
| 产品编号 | bsm-1622M |
| 英文名称 | AFP(A4) Mouse mAb |
| 中文名称 | 甲胎蛋白单克隆抗体(检测) |
| 英文别名 | alpha Fetoprotein; alpha-fetoprotein; alpha 1 fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin; alpha fetoglobulin; alpha Fetoprotein; alpha fetoprotein precursor; FETA; HPAFP; FETA_HUMAN. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Mouse |
| 免疫原 | AFP protein |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 理论分子量 | 65 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 研究领域 | Cancer > Tumor biomarkers > Tumor antigens Cardiovascular > Blood > Serum Proteins Developmental Biology > Organogenesis > Gut development > Liver development Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cardiovascular ELISA kits |
| 亚基 | Dimeric and trimeric forms have been found in addition to the monomeric form. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Plasma. Synthesized by the fetal liver and yolk sac. |
| 翻译后修饰 | Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence. Sulfated. |
| 相似性 | Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains. |
| 功能 | Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 6.641 }}] {Zhao J et al. A SERS-based immunoassay for the detection of α-fetoprotein using AuNS@ Ag@ SiO2 core-shell nanostars. Journal of Materials Chemistry C. 2019.} {Other} {}
[IF={{ 6.45 }}] {Lin, Dajie, et al. "Cascade signal amplification for electrochemical immunosensing by integrating biobarcode probes, surface-initiated enzymatic polymerization and silver nanoparticle deposition." Biosensors and Bioelectronics (2014).} {Other} {=""}
[IF={{ 6.277 }}] {Zhao CR et al. Highly sensitive and selective electrochemical immunosensors by substrate-enhanced electroless deposition of metal nanoparticles onto three-dimensional Graphene@Ni foams. Science Bulletin.2019.} {Other} {}
[IF={{ 5.88 }}] {Zhang, Xin, et al. "Spectrum-Based Electrochemiluminescent Immunoassay with Ternary CdZnSe Nanocrystals as Labels." Analytical Chemistry (2016).} {Other} {=""}
[IF={{ 5.83 }}] {Zong, Chen, et al. "Chemiluminescence imaging immunoassay of multiple tumor markers for cancer screening." Analytical Chemistry 84.5 (2012): 2410-2415.} {Other} {="Human"}
。常用的抗体有： ①单克隆小鼠抗人细胞角蛋白(Monoclonal mouse anti human cytokeratin)克隆为MNF116。 该抗体应用范围，各类的冰冻切片，涂片，细胞培养 片和经甲醛固定石蜡包埋的组织切片 。用本抗体检测的阳性组织有：鳞状上皮，甲状腺滤泡上皮消化道上皮，胰腺胆管上皮，肝胆管上皮，角膜上皮等以及发生于上述来源的肿瘤。应该注意的是有一些肿瘤在检测时，可出现两种阳性物，即用两种抗体来检测如采用CK和Vimentin，可出现双向表达阳性的肿瘤
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